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Immunology - Ch 2

End of chapter questions (cells, organs & microenvironment of immune system)

QuestionAnswer
Why is this false: there are no mature T cells in the bone marrow Although T cells complete their maturation in the thymus, not the bone marrow, mature CD4+ & CD8+ T cells will recirculate back to the bone marrow
Why is this false: the pluripotent stem cell is one of the most abundant cell types in the bone marrow Pluripotent hematopoietic stem cells are rare, representing less than 0.05% of cells in the bone marrow
Why is this false: there are no stem cells in the blood Hematopoietic stem cells can be mobilized from the bone marrow & circulate in the blood, which is now used as a source of stem cells for transplantation
Why is this false: activation of macrophages increases their expression of MHC I molecules, allowing them to present antigen to helper T cells more effectively Macrophages will increase both class I & class II MHC expressionafter activation; however, helper T cells are CD4+ & recognize antigenic peptide bound to class II MHC
Why is this false: mature B cells are closely associated with osteoblasts in the bone marrow Immature, not mature B cells, are associated w/ osteoblasts, which help them to develop
Why is this false: lymphoid follicles are present only in the spleen & lymph nodes Lymphoid follicles are found in all secondary lymphoid tissues, including that associated w/ mucosal tissues (MALT)
Why is this false: the FRC guides B cells to follicles The follicular dendritic cell (FDC)network guides B cells within follicles. The follicular reticular cell(FRC)system guides T cells w/i the T cell zone
Why is this false: infection has no influence on the rate of hematopoiesis Infection & associated inflammation stimulates the release of cytokines & chemokines that enhance blood cell development (particularly to the myeloid lineage)
Why is this false: follicular dendritic cells can process & present antigen to T lymphocytes FDC present soluble antigen on their surfaceto B cells, not T cells
Why is this false: dendritic cells arise only from the myeloid lineage Dendritic cells can arise from both myeloid & lymphoid precursors
Why is this false: all lymphoid cells have antigen-specific receptors on their membrane B & T lymphocytes have antigen specific receptors on their surface, but NK cells, which are also lymphocytes do not
What are the 2 primary roles of the thymus? Generation & the selection of a supply of T cells that will protect the body from infection
At what age does the thymus reach its maximal size? In humans, the thymus reaches maximal size during puberty. During the adult years, the thymus gradually atropies
What is the difference between a monocyte & a macrophage? Monocytes are blood-borne precursors of macrophages. Monocytes have limited phagocytic & microbial killing capacity compared to macrophages. Macrophages are larger, have increased phagocytosis & secretion of cytokines & other immune system modulators.
Created by: Thommy413
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