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Immunology Test 1

Leukocyte migration, innate immunology

QuestionAnswer
Hold tissue cells together, interactions between immune cells, interactions between leukocytes and blood vessel walls CAM: cell adhesion molecules
TNF-alpha, interleukin-1, IFN-gamma, histamine, thrombin, complements, other chemokiines chemicals/ mediators that cause expression of CAMs
These CAMs are found on activated endothelial cells, expressed in response to IFN-gamma, TNF-alpha, and LPS; and bind to mucin like receptors on neutrophils E-selectin
Short lived selectin, found on endothelium, activated by histamine, thrombin, and compliment, binds b and t cells P-selectin
Selectin found on leukocytes, always present, used to enter lymph tissue L- selectin
These CAMs bind to selectins mucin-like family: CK34, GlyCAM-1 (on HEVs), PSGL-1 on neutrophils
This CAM family is found on endothelial cells and binds to integrins. ex ICAM-1, ICAM-2, VCAM, MadCAM Immunoglobulin superfamily
this CAM has IG like properties and mucin like properties, therefore binds to integrins and selectins MAdCAM
found on Leukocytes, bind to Ig-like family, comprised of 2 polypeptide chains. expressed after initial attachment with selectin. help with homing to lymph organs Integrins
CAMs found on leukocytes Mucin, L-Selectins, integrins
CAMs found on endothelial cells Musins, E and P selectins, Ig superfamily
Migration of cells to an area of inflammation in response to chemotactic factors- migration to higher concentration of those factors Chemotaxis
LPS is found on gram ________ bacteria. negative
MBL, ficolin, and C1q bind to _______ on phagocytic cells. CD91
membrane bound PRR, binds to sugars, acts as opsonin CLR (c-type lectin receptor)
healthy cells exhibit _______ which inhibits phagocytosis. CD47
PRR: acute phase protein, acts as opsonin, actives lectin pathway mannose-binding lectin MBL
PRR: binds to LPS and glucose on gram + bacteria, activates classical pathway, opsonin, acute phase protein C reactive protein
opsonin, activates lectin complement pathway, found in mucosa, cause release of anti-inflammatory cytokines after phagocytosis ficolin
Source of C5a and C3a complement system
Source of f,met-leu-phe released by bacteria
source of leukotriene B4 Arachadonic acid metabolism in lipoxygenase pathway- occurring in leukocytes
source of Platelet activating factor (PAF) breakdown of membrane phospholipids
MIP-α, MIP-1β, MCP-1, RANTES CC subgroup chemokines
IL-8 NAP-2, PF-4 CXC subgroup chemokines
E-selectin of the skin binds to ___ during rolling of activated leukocytes CLA
MadCAM in the endothelium of the mucosa binds to _____ on activated leukocytes integrin α4β7- LPAM-1
only soluble PRR that is not an opsonin, acute phase protein, binds to CD14 on phagocytes, LBP
PRR produced by type II endothelial cells, binds to carbs, proteins, and lipids on cell walls of micro organisms Surfactant proteins A and D
This TLR works with CD14 and LBP TLR 4
PRR that serves as a corecptor of TLR2/6, role in atherosclerosis and hep C entry into cells scavenger receptors SR, SR-A, SR-B
mannose receptor, dectin-1, dectin-2, DC-SIGN are all what group of PRRs? CLR- c-type lectin receptor
The only group of membrane bound PRRs that act as opsonins. CLR
2 examples of intracellular PRRs NOD-like receptors(NLR) and retinoic acid inducible gene-I-like receptors (RLRs)
intracellular PRR that recognizes gram positive bacteria NLR- NOD like receptors
intracellular PRR that recognize RNA from viruses RLRs
Natural killer cells release cytokines when activated: IFN-gamma, granzymes, perforins
In chronic inflammation ___________&__________ secrete IFN-gamma causing activated macrophages Natural killer cells and TH1 cells
Created by: kaFoster
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