Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
antibotics part 3
| Question | Answer |
|---|---|
| widespread emergence of bacterial resistance to tetracycides and macrolides has drivena new class of antibiotics called what? | Streptogrammins |
| why were streptogrammins made | first synthetic antibiotic made to fight bacterial resistance to tetracyclides and macrolides |
| which drug is a streptogrammin | quinuristine-dalfopristine |
| quinupristine-dalfoprisiting is classed as what? | streptogrammin |
| what is important about streptogrammin amongst other drugs that inhiit protein synthesis? | it is rapidly bacteriocidal instead of bacteriostatic |
| which drug to treat vnavomycin resistant infections? | streptogrammin - quinupristine-dalfopristine |
| what does quinupristine-dalfoprisitne treat? | multi-drug resistant gram positive organisms and vnacmycin resistant infections |
| which drug is an oxazolidinone | linezolid (zyvox) |
| what does linezolid treat | drug resistant gram post organismes like MRSA, VRE |
| which durgs are aminoglycocides? | Streptomycin, gentamicin, tobramycin, |
| describe the davis model | drugs cause bacteria to make faulty proteins leading to damage and eventual bacteria cell death |
| what does aminoglycocides treat? | gram negative enteric bacteria |
| administering aminoglycosides | often given with other drugs ike beta lactams and vanco for sundergistic mechanisms and extended coverage |
| which amino glycosides are used topically? | tobramycin and kanamycin |
| what is tobramycin used for | aminoglycoside inhalation for p. aeruginosa |
| aminoglycoside route | not given orally poor bioavailabilit |
| side effects of aminoglycosides | otto and nephrotoxicity |
| how is resistance made to aminoglycocides? | inactivation of bacterial enzyes, decreased penetration, mutation of 30s ribsomal subunit so aminoglycoside ownt beable to bind to it |
| which drugs inhibit DNA synthesis? | antifolate drugs, DNA gyrase inhibitors |
| which drug is an antifolate drug? | sulfonamides and pyrimidine like trimethroprim |
| why is folate needed | to make purines for nucleic acid |
| how does sulfonamide work | competes with PABA for Dihydopteroate enzyme. looks like PABA |
| what is dihydopteroate used for | to make purines and thus build DNA |
| wy is resistance such a big problem with sulfa? | everyone has had a sulfa drug |
| how does trimethroprim work? | inhibits dihydrofolate reductase in protozoa |
| why do antifolate drugs not affect human cells? | unlike bacteria we do not make our own folat we get ours from dietary intake. |
| how are drugs resistant to sulfa? | over productions of PABA, lower affinity for drug, permeability to drug is decreased |
| which drug is mainstay for UTI infections? | Trimethoprim/Sulfamethoxazole |
| adverse effect of sulfanomide | fever, skin rash rarely stevens johnson syndrme, urine precipitates |
| what is important to know baout drugs that affect folate | it also affects rapidly dividing cells adn can cause bonemarrow supression |
| which drug is a pyrimethamine | trimethoprim analog |
| whatother infections can trimethoprim be used for | protozoa infections like leshmaniasis , toxoplasmosis |
| if a woman has had a rash from using bactrim and anaphylaxis with penicillin how else can we treat ehr uti | fluroquinolones |
| how does flouroquinolone work | inhibit DNA gyrase which prevents uncoiling of DNA and thus prevenitng replicaiton and transcription |
| what is DNA gyrase | it is an enzyme that removes the coiling of DNA strands so it an be transcribed and replciated |
| ow are florouquinolones excreted | Renal |
| how are resistnace to fluroquinoloes devlpe? | most common in staph and pseudomonas infections, mutation of DNA gyrase binding site, high cross resistance to all fluroquinolone |
| which drugs are fluroquinolones | ciprofloxacin, levoflocacin, moxifloxacin, |
| adverse effect of fluroquinolones | generally well tolerated, potential for QT elongation esleiall with class 1 and 2 antiarrythmic drugs and worse with hypokalemia |
| should flouroquinolones be given to children? |
Created by:
Cherry5301
Popular Nursing sets