Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.

Remove ads
Don't know
Know
remaining cards
Save
0:01
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards




share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

antibotics part 3

QuestionAnswer
widespread emergence of bacterial resistance to tetracycides and macrolides has drivena new class of antibiotics called what? Streptogrammins
why were streptogrammins made first synthetic antibiotic made to fight bacterial resistance to tetracyclides and macrolides
which drug is a streptogrammin quinuristine-dalfopristine
quinupristine-dalfoprisiting is classed as what? streptogrammin
what is important about streptogrammin amongst other drugs that inhiit protein synthesis? it is rapidly bacteriocidal instead of bacteriostatic
which drug to treat vnavomycin resistant infections? streptogrammin - quinupristine-dalfopristine
what does quinupristine-dalfoprisitne treat? multi-drug resistant gram positive organisms and vnacmycin resistant infections
which drug is an oxazolidinone linezolid (zyvox)
what does linezolid treat drug resistant gram post organismes like MRSA, VRE
which durgs are aminoglycocides? Streptomycin, gentamicin, tobramycin,
describe the davis model drugs cause bacteria to make faulty proteins leading to damage and eventual bacteria cell death
what does aminoglycocides treat? gram negative enteric bacteria
administering aminoglycosides often given with other drugs ike beta lactams and vanco for sundergistic mechanisms and extended coverage
which amino glycosides are used topically? tobramycin and kanamycin
what is tobramycin used for aminoglycoside inhalation for p. aeruginosa
aminoglycoside route not given orally poor bioavailabilit
side effects of aminoglycosides otto and nephrotoxicity
how is resistance made to aminoglycocides? inactivation of bacterial enzyes, decreased penetration, mutation of 30s ribsomal subunit so aminoglycoside ownt beable to bind to it
which drugs inhibit DNA synthesis? antifolate drugs, DNA gyrase inhibitors
which drug is an antifolate drug? sulfonamides and pyrimidine like trimethroprim
why is folate needed to make purines for nucleic acid
how does sulfonamide work competes with PABA for Dihydopteroate enzyme. looks like PABA
what is dihydopteroate used for to make purines and thus build DNA
wy is resistance such a big problem with sulfa? everyone has had a sulfa drug
how does trimethroprim work? inhibits dihydrofolate reductase in protozoa
why do antifolate drugs not affect human cells? unlike bacteria we do not make our own folat we get ours from dietary intake.
how are drugs resistant to sulfa? over productions of PABA, lower affinity for drug, permeability to drug is decreased
which drug is mainstay for UTI infections? Trimethoprim/Sulfamethoxazole
adverse effect of sulfanomide fever, skin rash rarely stevens johnson syndrme, urine precipitates
what is important to know baout drugs that affect folate it also affects rapidly dividing cells adn can cause bonemarrow supression
which drug is a pyrimethamine trimethoprim analog
whatother infections can trimethoprim be used for protozoa infections like leshmaniasis , toxoplasmosis
if a woman has had a rash from using bactrim and anaphylaxis with penicillin how else can we treat ehr uti fluroquinolones
how does flouroquinolone work inhibit DNA gyrase which prevents uncoiling of DNA and thus prevenitng replicaiton and transcription
what is DNA gyrase it is an enzyme that removes the coiling of DNA strands so it an be transcribed and replciated
ow are florouquinolones excreted Renal
how are resistnace to fluroquinoloes devlpe? most common in staph and pseudomonas infections, mutation of DNA gyrase binding site, high cross resistance to all fluroquinolone
which drugs are fluroquinolones ciprofloxacin, levoflocacin, moxifloxacin,
adverse effect of fluroquinolones generally well tolerated, potential for QT elongation esleiall with class 1 and 2 antiarrythmic drugs and worse with hypokalemia
should flouroquinolones be given to children?
Created by: Cherry5301