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Stack #145910

actions of neuroleptic drugs can be antagonized by Drugs that increase dopamine like levodopa and amphetamine or mimic dopamine like bromocriptine.
Which drug is used to counteract prolactin secretion arising pituitary toumors Bromocriptine
thist first generation agent can bind D1, D2, 5HT2, histamine H1 and a2 in the brain. Haloperidol
adverse effects including tachycardia, impotence, and dizziness are due to non-selective alpha adrenergic stimulation.
Weight gain and sedation is due to what receptor stimulation? Histamine H1
this more selective atypical drug binds D2 5HT2 and a2 Rispiridone
these type of agents bind dopamine receptors typical
these agents bind dopamine and serotonin receptors atypical-these are less sticky and bind then fall off
T/F blocking serotonin causes an increase release of dopamine True
T/F serotonin itself will block the release of dopamine True
Delusions, hallucinations, disorganized speech/behavior, agitation are examples of? positive symptoms
passivity, apathetic social withdrawal, stereotyped thinking anhedonia, attention impairment, emotional withdrawal are examples of Negative symptoms
impaired verbal fluency, problems with serial learning, problems with focused attention, concentration are examples of? cognitive symptoms
increase in dopamine in this pathway causes positive symptoms mesolimbic pathway
defecit of dopamine in this pathway causes negative and cognitive symptoms. Mesocortical pathway
part of extrapyramidal system and controls movment Nigrstriatal pathway
increase neuronal activity in this pathway inhibits prolactin release. Blockaed of D2 receptor increases prolactin release. tuberoinfundibular pathway
D2 blockade in this path relieves positive symptoms mesolimbic
D2 blockade in this path worsens negative symptoms mesocortical
D2 blockade in this path produces EPS symptoms like parkinsonian, tardive dyskinisias, or hyperkinetic movement disorders nigrostriatal
D2 blockade in this path casues prolactinemia tuberinfundibular path
low potency meds cause sedation, anti-ACH, and orthostatic hypotension.
Highpotency drugs cause EPS
clinical consequences of D2 blockade EPS movement disorders, endocrine changes, and sexual dysfunction
histamine blockade causes sedation, drowsiness, weight gain, hypotension
Alpha-1 receptor blockade causes Posteral hypotension, reflex tachycardia, dizziness
muscarinic blockade causes (anti-ACH) blurred vision, dry mouth, sinus tachycardia, constipation, urniary retention, memory dysfunction
this activity can cause EPS so drugs with this anti activity will be less likely to cause EPS cholinergic activity-therefore when high potency antipsychotics are precribed we will give anticholinergics.
This drug has affinity for D1, D4, 5HT2, muscarinic, and Alpha adrenergic receptors but is also a D@ antagonist clozapine
These agent blocks 5HT2 receptors to a greater extent than D2 Rispiridone and olanzapine
this agent is a partial agonist at D2 and a partial agonist at 5HT1A and an antagonist at 5HT2A. Also has moderate affinity for H1 and cholinergic muscarinic receptors aripiprizole
this agent blocks D2 more potently than5HT2a receptors but is consideered weak overall. It is low risk for EPS due to short period of time it binds to D2 quetiapine
Which drugs particularly block cholinergic (muscarinic receptors? thioridazine, chlorpromazine
Which drugs particularly block H1 receptors? Chlorpromazine and clozapine
Which drugs particularly block serotonin receptors? Rispiradone and Clozapine
Which drugs particularly block Dopamine all do but Strongest blockers are haloperidol, fluphenazine, and thiothixene
Which drug particularly blocks Alpha receptors chlorpromazine
Possible Clinical consequences of D2 blockade EPS, endocrine changes, sexual dysfunction
This drug is a partial agonist at D2 and 5HT1 and antagonist to 5ht2, it also shows maderate affinity for histamine, and alpha but no real affect of muscarenic Aripiprazole
Quetiapine blocks D2 more potently than 5HT2a receptors but is relatively weak at blocking either receptor and is low risk for EPS. quetiapine
all psych drugs have antiemetic effect except for these drugs . Aripiprazole and thiordizine -antiemetic effects occur through blockage of CTZ
produce anticholinergic effects including blurred vision, dry mouth, constipation, urine retention thiordizine, chlorpromazine, clozapine and olanzapine.
sedation occurs with D2 blocking of H1 receptors with these drugs Chlopromazine, clozapine, olanzapine, and quetiapine
drug induced nausea can be treated with this. Prochloperazine
nausea from motion should be treated with? antihistamines, sedatives and anti-cholinergics rather than antipsychotics
hiccups and pruritis can be treated with this chlorpromazine
disruptive behavior in autism can be treated with this rispiradone
Noncompliant patients can be treated with long acting drugs like fluphenazine deconate, haloperidol deconate, and risperidone microspheres (upto 2-4 weeks)
these drugs are contraindicated in patients with seizure symptoms. chlorpromazine and clozapine
T/F antipsychotics lower seizure threshold True
T/F Atypical drugs decrease mortality in dementia related behavioral disturbances and psychosis False they increase mortality
Created by: svaldez