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schizophrenia
Stack #145910
| Question | Answer |
|---|---|
| actions of neuroleptic drugs can be antagonized by | Drugs that increase dopamine like levodopa and amphetamine or mimic dopamine like bromocriptine. |
| Which drug is used to counteract prolactin secretion arising pituitary toumors | Bromocriptine |
| thist first generation agent can bind D1, D2, 5HT2, histamine H1 and a2 in the brain. | Haloperidol |
| adverse effects including tachycardia, impotence, and dizziness are due to | non-selective alpha adrenergic stimulation. |
| Weight gain and sedation is due to what receptor stimulation? | Histamine H1 |
| this more selective atypical drug binds D2 5HT2 and a2 | Rispiridone |
| these type of agents bind dopamine receptors | typical |
| these agents bind dopamine and serotonin receptors | atypical-these are less sticky and bind then fall off |
| T/F blocking serotonin causes an increase release of dopamine | True |
| T/F serotonin itself will block the release of dopamine | True |
| Delusions, hallucinations, disorganized speech/behavior, agitation are examples of? | positive symptoms |
| passivity, apathetic social withdrawal, stereotyped thinking anhedonia, attention impairment, emotional withdrawal are examples of | Negative symptoms |
| impaired verbal fluency, problems with serial learning, problems with focused attention, concentration are examples of? | cognitive symptoms |
| increase in dopamine in this pathway causes positive symptoms | mesolimbic pathway |
| defecit of dopamine in this pathway causes negative and cognitive symptoms. | Mesocortical pathway |
| part of extrapyramidal system and controls movment | Nigrstriatal pathway |
| increase neuronal activity in this pathway inhibits prolactin release. Blockaed of D2 receptor increases prolactin release. | tuberoinfundibular pathway |
| D2 blockade in this path relieves positive symptoms | mesolimbic |
| D2 blockade in this path worsens negative symptoms | mesocortical |
| D2 blockade in this path produces EPS symptoms like parkinsonian, tardive dyskinisias, or hyperkinetic movement disorders | nigrostriatal |
| D2 blockade in this path casues prolactinemia | tuberinfundibular path |
| low potency meds cause | sedation, anti-ACH, and orthostatic hypotension. |
| Highpotency drugs cause | EPS |
| clinical consequences of D2 blockade | EPS movement disorders, endocrine changes, and sexual dysfunction |
| histamine blockade causes | sedation, drowsiness, weight gain, hypotension |
| Alpha-1 receptor blockade causes | Posteral hypotension, reflex tachycardia, dizziness |
| muscarinic blockade causes (anti-ACH) | blurred vision, dry mouth, sinus tachycardia, constipation, urniary retention, memory dysfunction |
| this activity can cause EPS so drugs with this anti activity will be less likely to cause EPS | cholinergic activity-therefore when high potency antipsychotics are precribed we will give anticholinergics. |
| This drug has affinity for D1, D4, 5HT2, muscarinic, and Alpha adrenergic receptors but is also a D@ antagonist | clozapine |
| These agent blocks 5HT2 receptors to a greater extent than D2 | Rispiridone and olanzapine |
| this agent is a partial agonist at D2 and a partial agonist at 5HT1A and an antagonist at 5HT2A. Also has moderate affinity for H1 and cholinergic muscarinic receptors | aripiprizole |
| this agent blocks D2 more potently than5HT2a receptors but is consideered weak overall. It is low risk for EPS due to short period of time it binds to D2 | quetiapine |
| Which drugs particularly block cholinergic (muscarinic receptors? | thioridazine, chlorpromazine |
| Which drugs particularly block H1 receptors? | Chlorpromazine and clozapine |
| Which drugs particularly block serotonin receptors? | Rispiradone and Clozapine |
| Which drugs particularly block Dopamine | all do but Strongest blockers are haloperidol, fluphenazine, and thiothixene |
| Which drug particularly blocks Alpha receptors | chlorpromazine |
| Possible Clinical consequences of D2 blockade | EPS, endocrine changes, sexual dysfunction |
| This drug is a partial agonist at D2 and 5HT1 and antagonist to 5ht2, it also shows maderate affinity for histamine, and alpha but no real affect of muscarenic | Aripiprazole |
| Quetiapine blocks D2 more potently than 5HT2a receptors but is relatively weak at blocking either receptor and is low risk for EPS. | quetiapine |
| all psych drugs have antiemetic effect except for these drugs . | Aripiprazole and thiordizine -antiemetic effects occur through blockage of CTZ |
| produce anticholinergic effects including blurred vision, dry mouth, constipation, urine retention | thiordizine, chlorpromazine, clozapine and olanzapine. |
| sedation occurs with D2 blocking of H1 receptors with these drugs | Chlopromazine, clozapine, olanzapine, and quetiapine |
| drug induced nausea can be treated with this. | Prochloperazine |
| nausea from motion should be treated with? | antihistamines, sedatives and anti-cholinergics rather than antipsychotics |
| hiccups and pruritis can be treated with this | chlorpromazine |
| disruptive behavior in autism can be treated with this | rispiradone |
| Noncompliant patients can be treated with | long acting drugs like fluphenazine deconate, haloperidol deconate, and risperidone microspheres (upto 2-4 weeks) |
| these drugs are contraindicated in patients with seizure symptoms. | chlorpromazine and clozapine |
| T/F antipsychotics lower seizure threshold | True |
| T/F Atypical drugs decrease mortality in dementia related behavioral disturbances and psychosis | False they increase mortality |
Created by:
svaldez
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