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P JESSIE PHARM CH 4
PHARMACODYNAMICS CH 4
| Question | Answer |
|---|---|
| antihistamines | drug plus the receptor or drug receptor complex |
| acetylcholine | hormone which has properties that control certain neurotransmitters |
| site of action | FDA requires the companies that manufacture drugs to prove the drug works and its safe. |
| hypothalamus | located in the brain,the bodys temperture regulator |
| mechanism of action | explains how a drug works & produces its desirable and undesirable effects |
| receptor site | location where the drug binds to the cell |
| agonist | type of drug that,when it binds to the correct receptor produces a certain,predicted action.agonists bind & produce cellular responses resulting in a therapeutic effect.agonists have two main properties affinity & efficacy |
| antagonist | is a drug that when it binds to a specific receptor on the cell does not produce any noticeable effect.they reduce the action of a agonist at the receptor site involved. |
| affinity | ability of the agonist to bind to the cell receptor structure |
| efficacy | (agonist)the ability the drug imposes on the cell & its structure & how well it changes the waythe cell behaves |
| efficacious | agonist that does what it is designed to do |
| target cell | large number of cells that are similar(nerve cells,cells of the heart or vascular system,ciculation & blood pressure) |
| dose response curve | the response of a drug is directly related to the amount of drug taken or given. |
| potency | measurement of the strength of the drug that is required to have a specific effect on the body. |
| ED50 | the measurement of the amount of a drug that will achieve one half of the maximal response |
| time response curve | a curve that gives the observer a means to determine the length of time in which a drug will continue to have the same degree of effect on a class of cells,organ,body what is being treated. |
| pharmacodynamic mechanism | problem related to drug-drug interactions occur because of the addition of a drug that is antagonistic in nature to one that is not or adding an antagonistic drug to a number of drugs that are alresdy designed to be antagonistic |
| hypotension | abnormally low blood pressure |
| metabolites | any substance produced by the metabolic process |
| Structures on the cells that interact with a specific drug because they have a specific structure that permits the drug to fit are called | receptors |
| Mechanism of action | a term that explains essentially how a drug works and produces its desirable effects |
| Antihistamines turn off the parts of certain cells in the body that cause the common symptoms of allergies,which are | red eyes,funny nose |
| Acetylcholine is a | hormone |
| Describe how an opiod helps a patient in pain.What happens in the body? | 1 |
| Describe the difference between an agonist and an antagonist and give an example of each. | 1 |
| Agonists have two main properties.They are | affinity and efficacy |
| Explain why,just because a drug does not produce a noticeable effect,it does not mean that the drug does not work | 1 |
| The response of a drug that is directly related to the amount of the grug taken or given is referred to as | dose response curve |
| Warfarins active ingredient is the same ingredient found in what household product? | rat poison |
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PAJJ21
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