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P JESSIE PHARM CH 4

PHARMACODYNAMICS CH 4

QuestionAnswer
antihistamines drug plus the receptor or drug receptor complex
acetylcholine hormone which has properties that control certain neurotransmitters
site of action FDA requires the companies that manufacture drugs to prove the drug works and its safe.
hypothalamus located in the brain,the bodys temperture regulator
mechanism of action explains how a drug works & produces its desirable and undesirable effects
receptor site location where the drug binds to the cell
agonist type of drug that,when it binds to the correct receptor produces a certain,predicted action.agonists bind & produce cellular responses resulting in a therapeutic effect.agonists have two main properties affinity & efficacy
antagonist is a drug that when it binds to a specific receptor on the cell does not produce any noticeable effect.they reduce the action of a agonist at the receptor site involved.
affinity ability of the agonist to bind to the cell receptor structure
efficacy (agonist)the ability the drug imposes on the cell & its structure & how well it changes the waythe cell behaves
efficacious agonist that does what it is designed to do
target cell large number of cells that are similar(nerve cells,cells of the heart or vascular system,ciculation & blood pressure)
dose response curve the response of a drug is directly related to the amount of drug taken or given.
potency measurement of the strength of the drug that is required to have a specific effect on the body.
ED50 the measurement of the amount of a drug that will achieve one half of the maximal response
time response curve a curve that gives the observer a means to determine the length of time in which a drug will continue to have the same degree of effect on a class of cells,organ,body what is being treated.
pharmacodynamic mechanism problem related to drug-drug interactions occur because of the addition of a drug that is antagonistic in nature to one that is not or adding an antagonistic drug to a number of drugs that are alresdy designed to be antagonistic
hypotension abnormally low blood pressure
metabolites any substance produced by the metabolic process
Structures on the cells that interact with a specific drug because they have a specific structure that permits the drug to fit are called receptors
Mechanism of action a term that explains essentially how a drug works and produces its desirable effects
Antihistamines turn off the parts of certain cells in the body that cause the common symptoms of allergies,which are red eyes,funny nose
Acetylcholine is a hormone
Describe how an opiod helps a patient in pain.What happens in the body? 1
Describe the difference between an agonist and an antagonist and give an example of each. 1
Agonists have two main properties.They are affinity and efficacy
Explain why,just because a drug does not produce a noticeable effect,it does not mean that the drug does not work 1
The response of a drug that is directly related to the amount of the grug taken or given is referred to as dose response curve
Warfarins active ingredient is the same ingredient found in what household product? rat poison
Created by: PAJJ21