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First Aid - Microbiology

Same btwn gram+ and gram- flagellum, pilus, capsule, peptidoglycan, cytoplasmic membrane
unique to gram positive lipoteichoic acid (combo of lipids and teichoic acids), has a cell wall
unique to gram negative endotoxin, lipopolysaccharide outer membrane, periplasm
mycoplasmas have no cell walls (do not gram stain) , also contain sterols
mycobacteria TB, contain mycolic acid, high lipid content, detected by acid fast stain
obligate aerobes O2 dependent, ex. pseudomonas aeruginoasa (burns, diabetes, pneumonia), TB - reactivation of TB goes to apices of long b/c highest pO2
obligate anaerobes lack catalase and/or superoxide dismutase susceptible to oxidative damage, normal flora in GI tract, but pathogenic elsewhere
encapsulated bacteria capsules serve as antiphagocytic virulence factor, capsule + protein conjugate serve as an antigen in vaccines, strep pneumoniae, H. flu, E.coli, salmonella, Klebsiella pneumonia. usually opsonized and cleared by spleen. asplenics at risk for severe dz
Created by: Smukadam