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SSRIs for Depression and Anxiety

SSRIs for Depress and AnxietyDrug name
Fluoxetine Prozac
Sertraline Zoloft
Paroxetine Paxil
Citalopram Celexa
Fluvoxamine Luvox
Side effects SSRIs Sexual, GI distress, agitation, insomnia, tremor, diarrhea
Toxicity? Serotonin syndrome: fever, myoclonus, mental status changes, CV collapse)
How toxicity? If taken with MAOI, increases serotonin b/c one inhibits reuptake and other inhibits degradation
How is MAOI toxicity precipitated? Eating foods with tyramine (red wine, cheese) b/c it is broken down by MAO but if inhibited it will increase to toxic levels
Created by: MatAnt