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Urinary 2 - Renal Ph

Urinary 2 - Renal Physiology

What is the barrier between blood and capsular space? glomerular capillary endothilium + visceral capsular cells (podocytes)
What does not get past this glomerular cappilary epithilium + visceral capsular cells (podocyte) layer? Platelets Cells Large protiens
What are the specific layers of the barrier? 1. glomerurular capillary endothilium (large pores, allow H2O +all solute) 2. basal lamina (acellular material b/w vasc. endothil & podocytes, neg charge, prevent protiens) 3. podocyte layer (cells of vasceral capsule) wrap around vascular ent cells
Mesangial cells cells located b/w afferent & efferent arteriolar cells can contract - regulating blood flow through casculature & altering glomerular blood flow rate
Filtration slits gaps between the pedicels of a podocyte layer (which wraps around vascular endo cells) Allow small molecules (h20, glucose, vit, amino acids, ammonia, urea, ions)
Albumin most plentiful plasma protien - too big to pass
Vessel size in afferent and efferent arteriole diameter of efferent vessels MUCH SMALLER hight flow resistance - increases BP in aff & glom caps
Blood Hydrostatic pressure forces out from the vessel 55mmHg
Capsular hydrostatic pressure Pushes back into vessel (Negative Pressure) -15
Plasma colloid osmotic pressure due to plasma protiens - Pulls fluid back from capsule into blood Negative Pressure (-30 mmHg)
Capsulat colloid osmotic pressure Zero Protiens in general dont have access to capsule in a normal Kidney
NET Filtration Pressure 10mmHG outward force through the gaps of vessel walls
Glomerular Filtration Rate (GFR) STRONGLY DEPENDS ON GLOMERULAR BLOOD FLOW filtrate produced by both kidnyes in one minute MAP = 80-180 mmHG Male - 125mL/min Female - 100mL/min
How is GFRate regulated? 1. by adjusting glomerular blood flow (changes in diameters of afferent & efferent arterioles)
How is glomerular blood flow regulated? 1. renal autoregulation (ESSAY) 2. Neural regulation 3. Hormonal regulation
Renal Autoregulation myogenic mechanism - stretches of the afferent arteriole smooth muscle causes it to contract increasing the >BP - which causes stretch of vasc smooth muscle - causing it to contract - thereby constricting vessel - decreasing flow.
Autoregulation - Tubulorglomerular feedback macula densa sense excess H2O,Na & Cl. release nitric oxide - vaso dialoter to decrease the flow.
neuronal regulation innervated by symp fiber flight or flight hemmorage, low bp, shock >< urine prduction release NE constrics AFFERENT VASCULAR SMOOTH MUSCLE POOL BLOOD CENTERALLY
HORMONAL rEGULATION aNGIOTENSIN - constrict aff & eff Renin relese & ACE ANP - Atrial natriuretic peptide atrial stretch - cause mesangial cells to relax, > cap SA for filtriation.
Created by: Yourdanos
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