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NUR 100 Diabetes
Diabetes Mellitus
Term | Definition |
---|---|
Type 1 | the result of pancreatic islet cell destruction and no insulin production |
Type 2 | insulin resistance with a defect in compensatory insulin secretion |
Three types of cells in pancreas | Alpha Beta Delta |
Alpha cells | Produce glucagon breakdown of glycogen in the liver |
Glucoagon | Decrease glucose oxidation Increase blood glucose levels |
Glycogenolysis | Breakdown of liver glycogen |
Gluconeogenesis | Formation of glucose from fats and proteins |
Beta cells | Secretes insulin movement of glucose across cell membrane thus decreases blood glucose |
Delta cells | Produce somatostatin Neurotransmitter inhibits production of glucagon and insulin |
Pathophysiology of Diabetes | Defects in secretion of insulin Defects in action of insulin Or both problems |
Characteristics of Type 1 | Polyuria Polydipsia Polyphagia |
Characteristics of Type 2 | Decrease in insulin available Cellular resistance to insulin activity Hyperglycemia occurs slowly over time |
Treatment of DM | Weight loss Diet Excercise Hypoglycemic agents when needed |
Hemoglobin A1C | Measures levels of glycosylated hemoglobin |
Types of Insulin | Rapid acting Short acting Intermediate acting Long acting |
Sulfonylureas (TYPE2) | Increase insulin production Glipizide (Glucotorl) Glyburide (Diabeta) |
Meglitinides (TYPE2) | Stimulate pancreas |
Biguanides (TYPE2) | Reduces glucose production in the liver |
Alpha-Glucosidase Inhibitors (TYPE2) | slow the digestion of carbohydates in the small intestine |
D-Phenylalanine (Amino Acid) Derivative | Stimulates rapid and short insulin secretion from the pancreas |
Hypoglycemia | Tired Irritability Restless Excessive hunger Diaphoresis Depression |