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pysch pharm

First Aid psych pharm

antipsychotics (neuroleptics) haloperidol, -azine
atypical antipsychotics clozapine, olanzapine, risperidone, apripazole, quetiapine
SSRIs fluoxetine, sertraline, paroxetine, citalopram
TCAs impramine, amytriptyline
MAOIs phenelzine, selegiline, tranylcyprome
EtOH withdrawl treatment BZD
anorexia/bulimia treatment SSRI
atypical depression MAOI
bipolar treatment mood stabilizers: lithium, valproic acid, carbamazepine
depression treatment SSRI, TCA
depression with insomnia treatment trazadone (increases REM), mirtazapine (causes sedation)
OCD treatment SSRI, clomipramine (TCA)
panic disorder treatment TCA, busprione
schizophrenia treatment antipsychotics
Tourette's treatment haloperidol, olanzapine (atypical antipyschotic)
blocks D2 receptors antipsychotics (neuroleptics); D2 normally regulates NT release
block DA and 5HT(2) receptors atypical antipsyhotics
inhib phosphoninositol cascade lithium
stimulates 5HT(1A) receptor busprione
blocks NE and 5HT reuptake TCA
block DA, NE, 5HT reuptake venlafaxine
alpha-2 antag --> increase NE and 5HT release; 5HT(2) and 5HT(3) receptor antag mirtazapine
blocks NE uptake maprotiline
inhib 5HT reuptake trazadone
SE of antipsychotics (neuroleptics) EPS, neuroleptic malignant syndrome, tardive dyskinesia
EPS side effects 4 hours dystonia, 4 days akinesia (parkinsonism), 4 weeks akathesia (restlessness), 4 months tardive dyskinesia
tardive dyskinesia oral-facial movements due to DA receptor sensitization
neuroleptic malignant syndrome rigidity, myoglobinuria, autonomic instability, hyperpyrexia
treatement of neuroleptic malignant syndrome dantrolene, DA agonists
treatement of positive and negative symptoms of schizophrenia atypical anitpsychotics
OCD, anxiety, depression, mania, Tourette's treatment olanzapine
SE: agranulocytosis, requiring weekly WBC monitoring clozapine
SE: tremor, nephrogenic DI, hypoTN, pregnancy problems lithium
anxiolysis for generalized anxiety disorder; no sedation or addiction, no interaction with EtOH busprione
caused by taking SSRI and MAOI together serotonin syndrome
serotonin syndrome hyperthermia, muscle rigidity, CV collapse
SE: convulsions, coma, cardiotoxicity TCAs
used in smoking cessation bupropion
antidepressant that does NOT cause sexual SE bupropion
SE: increase REM, priapism trazadone
treatment for depressed elderly patient who is losing weight mirtazapine (SE: increased appetite)
contraindicated in treatement of depressed bulimic patient bupropion --> decreases seizure threshold
contraindicated with tyramine ingestion and B-agonists --> hyperthermia MAOI
contraindicated with SSRI and meperidine --> serotonin syndrome MAOI
Created by: anpham26



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