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Z - Pharmacology

First Aid - Pharm 4

QuestionAnswer
which anticholinesterase is extremely short acting Edrophonium
Cholinesterase inhibitor poisoning;;symps DUMBBEL ASS.;;Diarrhea, Urination, Miosis, ;Bronchospasm, Bradycardia, Excitation of skeletal ;muscle and CNS, Lacrimation, Abdominal cramping, Sweating, and Salivation
Cholinesterase inhibitor poisoning;;Tx Atropine (muscarinic antagonist) plus pralidoxime
chemical antagonist used to regenerate active cholinesterase pralidoxime
pralidoxime;;uses and mech Cholinesterase inhibitor poisoning;;chemical antagonist used to regenerate active cholinesterase
Parathion organophosphate
organophosphate toxicity mech Irreversible Cholinesterase inhibitor poisoning
Atropine, ;;mech Muscarinic antagonist
Benztropine ;;mech Muscarinic antagonist
Scopolamine ;;mech Muscarinic antagonist
Ipratropium ;;mech Muscarinic antagonist
Methscopolamine, ;oxybutin, ;glycopyrrolate ;;mech Muscarinic antagonist
Atropine;;clinical use Produce mydriasis and cycloplegia
Benztropine ;;clinical use Parkinson’s disease
Scopolamine ;;clinical use Motion sickness
Ipratropium ;;clinical use Asthma, COPD
Methscopolamine, ;oxybutin, ;glycopyrrolate ;;clinical use Reduce urgency in mild cystitis and reduce bladder spasms
Glaucoma drugs mech and side effects;;Epinephrine ↑ outflow of aqueous humor ;;Mydriasis, stinging; do not use;in closed-angle glaucoma
Glaucoma drugs mech and side effects;;Brimonidine ↓ aqueous humor synthesis ;;No pupillary or vision changes
Glaucoma drugs mech and side effects;;β-blockers ↓ aqueous humor secretion ;;No pupillary or vision changes
Glaucoma drugs mech and side effects;;Acetazolamide ↓ aqueous humor secretion due to ;↓ HCO3− (via inhibition of carbonic anhydrase);;No pupillary or vision changes
Glaucoma drugs mech and side effects;;Cholinomimetics ↑ outflow of aqueous humor; contract ciliary muscle and open trabecular meshwork;;;Miosis, cyclospasm
Glaucoma drugs mech and side effects;;Latanoprost (PGF2α) ↑ outflow of aqueous humor;;Darkens color of iris (browning)
which glaucoma drug ↑ outflow of aqueous humor Epinephrine;;Cholinomimetics;;Prostaglandin (Latanoprost ;(PGF2α))
which glaucoma drug ↓ aqueous humor synthesis Brimonidine
which glaucoma drug ↓ aqueous humor secretion β-blockers: Timolol, betaxolol, ;carteolol;;Diuretics: Acetazolamide
which glaucoma drug causes Mydriasis, stinging; do not use;in closed-angle glaucoma Epinephrine
which glaucoma drug causes Miosis, cyclospasm Cholinomimetics
which glaucoma drug causes Darkens color of iris (browning) Prostaglandin: Latanoprost ;(PGF2α)
Atropine effects dilates pupils and Blocks SLUD: ;↓Salivation;↓Lacrimation;↓Urination;↓Defecation
Atropine Toxicity Hot as a hare;Dry as a bone;Red as a beet;Blind as a bat;Mad as a hatter
Can cause acute angle-closure glaucoma in elderly, urinary retention in men with prostatic hypertrophy, and hyperthermia ;in infants. Atropine
Hexamethonium;;Mechanism Nicotinic ACh receptor antagonist. Ganglionic blocker.
Hexamethonium;;Clinical use Ganglionic blocker. Used in experimental models to prevent vagal reflex responses to ;changes in blood pressure– –e.g., prevents reflex bradycardia caused by NE.
prevents reflex bradycardia caused by NE Hexamethonium
Used in experimental models to prevent vagal reflex responses to ;changes in blood pressure Hexamethonium
selectivity for Sympathomimetics;;Epinephrine α1, α2, β1, β2, low doses selective for β1
selectivity for Sympathomimetics;;NE α1, α2 >β1
selectivity for Sympathomimetics;;;Isoproterenol β1 =β2
selectivity for;Sympathomimetics;;Dopamine D1 = D2 >β >α
selectivity for Sympathomimetics;;Dobutamine β1 >β2
Mechanism for Sympathomimetics;;Amphetamine Indirect general agonist, releases stored ;catecholamines
Mechanism for Sympathomimetics;;Ephedrine Indirect general agonist, releases stored ;catecholamines
Mechanism forSympathomimetics;;Cocaine Indirect general agonist, uptake inhibitor
Mechanism for Sympathomimetics;;Clonidine, α-methyldopa Centrally acting α-agonist, ↓ central ;adrenergic outflow
Created by: christinapham