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Pharmacology – First

Anti-cholinergics

QuestionAnswer
Cholinomimetics;direct;names Bethanechol ;Carbachol ;Pilocarpine ;Methacholine
Cholinomimetics;indirect;names Neostigmine ;Pyridostigmine ;Edrophonium ;Physostigmine ;Echothiophate
Bethanechol ;;Mech Cholinomimetics: Direct agonist
Carbachol ;;Mech Cholinomimetics: Direct agonist
Pilocarpine ;;Mech Cholinomimetics: Direct agonist
Methacholine ;;Mech Cholinomimetics: Direct agonist
Neostigmine ;;Mech Cholinomimetics: inirect agonist (anticholinesterase);;↑ endogenous ACh
Pyridostigmine ;;Mech Cholinomimetics: inirect agonist (anticholinesterase);;↑ endogenous ACh
Edrophonium ;;Mech Cholinomimetics: inirect agonist (anticholinesterase);;↑ endogenous ACh
Physostigmine ;;Mech Cholinomimetics: inirect agonist (anticholinesterase);;↑ endogenous ACh
Echothiophate ;;Mech Cholinomimetics: inirect agonist (anticholinesterase);;↑ endogenous ACh
Which Cholinergic Activates Bowel and Bladder smooth muscle; Bethanechol
Which Cholinergic Contracts ciliary muscle of eye (open angle), pupillary sphincter (narrow angle) Carbachol
Which Cholinergic Stimulates muscarinic receptors in airway when inhaled. Methacholine
Which Cholinergic ;;Potent stimulator of sweat, tears, saliva Pilocarpine
Which Cholinergic resistant to AChE Bethanechol and Pilocarpine
Which Cholinergic ↑ endogenous ACh No CNS penetration Neostigmine
Which Cholinergic ↑ endogenous ACh; ↑ strength Pyridostigmine
Which Cholinergic is used for Postoperative and neurogenic ileus and urinary ;retention Bethanechol ;and;Neostigmine
Which Cholinergic is used for Glaucoma, pupillary contraction, and release of intraocular pressure Carbachol, Echothiophate and Physostigmine
Which Cholinergic is used for Potent stimulator of sweat, tears, saliva Pilocarpine
Which Cholinergic is used for Challenge test for diagnosis of asthma Methacholine
Which Cholinergic is used for reversal of ;neuromuscular junction blockade (postoperative) Neostigmine
Which Cholinergic is used for Myasthenia gravis Neostigmine ;;Pyridostigmine does penetrate CNS
Which Cholinergic is used for Diagnosis of myasthenia gravis Edrophonium
Which Cholinergic is used for atropine overdose Physostigmine
Clinical applications of;;Bethanechol Postoperative and neurogenic ileus and urinary ;retention
Clinical applications of;;Carbachol Glaucoma, pupillary contraction, and release of ;intraocular pressure
Clinical applications of;;Pilocarpine Potent stimulator of sweat, tears, saliva
Clinical applications of;;Methacholine Challenge test for diagnosis of asthma
Clinical applications of;;Neostigmine Postoperative and neurogenic ileus and urinary ;retention, myasthenia gravis, reversal of ;neuromuscular junction blockade (postoperative)
Clinical applications of;;Pyridostigmine Myasthenia gravis; does penetrate CNS
Clinical applications of;;Edrophonium Diagnosis of myasthenia gravis (extremely short ;acting)
Clinical applications of;;Physostigmine Glaucoma (crosses blood-brain barrier → CNS) ;and atropine overdose
Clinical applications of;;Echothiophate Glaucoma
Created by: christinapham