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Pharmacology - First

First Aid - Pharm 1

28-year-old chemist presents ;with MPTP exposure. What neurotransmitter is depleted? Dopamine.
Woman taking tetracycline ;exhibits photosensitivity. Rash on sun-exposed regions of ;the body.
African-American man who ;goes to Africa develops a ;hemolytic anemia after taking ;malarial prophylaxis. Glucose-6-phosphate ;dehydrogenase de´Čüciency
Farmer presents with dyspnea, ;salivation, miosis, diarrhea, ;cramping, and blurry vision. Insecticide poisoning; inhibition of acetylcholinesterase.
27-year-old female with a history of psychiatric illness now has urinary retention due to a neuroleptic. What do you treat it with? Bethanechol.
Patient with recent kidney ;transplant is on cyclosporine for ;immunosuppression. Requires ;antifungal agent for candidiasis. What antifungal drug would result in cyclosporine toxicity? Ketoconazole.
Patient is on carbamazepine. What routine workup should always be done? LFTs.
23-year-old female who is on ;rifampin for TB prophylaxis and ;on birth control (estrogen) gets ;pregnant. Why? Rifampin augments estrogen ;metabolism in the liver, rendering it less effective.
concentration after no. of half-lives 1 - 50% ;2 - 75% ;3 - 87.5;3.3 - 90%;4 - 94%
28 year old chemist presents with MPTP exposure What NT is depleted? Dopamine
Woman taking tetracycline exhibits photosensitivity What are the clinical manifestations? Rash on sun-exposed regions of body
Nondiabetic patient presents with hypoglycemia but low levels of C peptide What is the diagnosis Surreptitious insulin injection
African American male who goes to Africa develops hemolytic anemia after taking malaria prophylaxis What is the enzyme defficiency Glucose 6 phosphate dehydrogenase
27 year old female with history of psychiatric illness now has urinary retention due to neuroleptic What do you treat it with? Bethanechol
Farmer presents with dyspnea, salivation, miosis, diarrhea, cramping and blurry vision What caused this and what is the mechanism Insecticide poisoning, inhibition of acetylcholinesterase
Patient with recent kidney transplant is on cyclosporine for immunosuppresion, he requires antifungal agent for candidiasis What antifungal drug would result in cyclosporine toxicity? Ketoconazole
Man on several medications including antidepressants and antihypertensives, has mydriasis and becomes constipated What is the cause of symptoms? TCA
55 year old postmenopausal woman on tamoxifen therapy What is she at increased risk of acquiring? Endometrial carcinoma
Woman on MAO inhibitor has hypertensive crisis after meal What did she ingest? Tyramine (wine or cheese)
After taking clindamycin, patient develops toxic megacolon and diarrhea What is the mechanism of diarrhea? Clostridium difficile overgrowth
Man starts a medication for hyperlipidemia. He then develops rash, pruritus and GI upset What drug was it? Niacin
Patient is on carbamazepine What routine workup should be done? LFT's
23 year old female who is on rifampin for TB prophylaxis and on birth control (estrogen) gets pregnant Why? Rifampin augments estrogen metabolism in liver rendering it less effective
Patient develops cough and must discontinue captopril WHat is a good replacement drug and why doesnt it have the same side effects? Losartan - an angiotensin II receptor antagonist, does not increase bradykinin as captopril does
After 1 half life concentration of drug equals _ % 0.5
After 2 half lifes concentration of drug equals_ 0.75
A drug infused at constant rate reaches about _ % of steady state after 4 T1/2 94
Created by: christinapham



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