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Immune System

Biology Test 2

QuestionAnswer
What are the two roles of the immune system? 1)fast aggressive response against non-self 2) discriminate between self and non-self
What are the two types of immunoresponses? Innate: Non-specific generic response Adaptive: Specific response tailored toward specific pathogen
What makes up the immune system Lymphatic system consists of lymph nodes: pockets of immune cells meant for localized response; cells can travel through blood to site of infection, and "resident" immune cells localize
What are some innate immune defenses? Skin and secretions: tears, stomach acid, mucus Cells and the inflammatory response
What is the Inflammatory Response? Macrophage detect; phagocytose and secrete cytokine (signal) Cytokines make endothelial cells leaky so neutrophils can exit capillary Neutrophils also increase phagocytosis
What are the two basic roles of adaptive immune response Humoral immunity (b-cell and antibodies) against extracellular Cell-mediated immunity (t-cells) intracellular
What protein drives the adaptive immune response? MHC: membrane bound proteins on surface of every host cell when protein complexed with ANTIGEN; elicits attack
How do cells build immunity Cytotoxic T cells kill ANY host cells with intracellular pathogen Each Tc has unique receptor
How do Host cells process a pathogen? -Processes pathogen and complexes it with MHC -Tc cell w/ correct receptor binds to cell -That Tc multiplies and kills all infected (host) cells
How does the humoral response work? Pathogen taken up by APC (macrophage), Pathogen presented with MHC Th w/ correct receptor multiplies Th binds to surface of correct b cell Bcell will secrete correct antibody, proliferate, antibodies will bind and inactivate
Th cell? Helper T cell! they also are specific, and can find the specific b cell they correspond with that will make the correct antibody to bind and inactivate the pathogen!
Created by: hannahprt
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