click below
click below
Normal Size Small Size show me how
HRegInt
Hormone Regulation and Integration
| Term | Definition |
|---|---|
| Adrenergic Receptors | are a class of G protein-coupled receptors that bind to catecholamines such as norepinephrine and epinephrine. |
| Affinity | describes the tightness of binding between a hormone and its receptor. It is quantified in terms of the concentration of hormone at which half of the available receptors are occupied. |
| Antagonism | the opposing action of ligands that when taken together decrease the effectiveness of at least one of them. |
| Atrial natriuretic factor | a vasodilator secreted by heart muscle cells to control water, sodium, potassium and fat levels. |
| Capacity | maximum response to a ligand that a tissue or organ can achieve, which depends upon the number of target cells and their competence |
| Dose response curve | is the relationship between the magnitude of a hormonal response and the concentration of a hormone that produces the response. |
| Feed Forward | anticipatory or preemptive chemical response that prepares the body for a change or a demand. |
| Glucagon | a hormone formed in the pancreas that acts in the liver to promote the breakdown of glycogen into glucose. |
| Glucocorticoids | steroid hormones that bind to glucocorticoid receptors to regulate glucose levels and decrease immune responses. |
| Half-maximal response | the concentration of hormone required to generate half of the maximum response that a cell can generate. |
| Negative Feedback | some consequence of hormone secretion that acts directly or indirectly on the secretory cells to inhibit further secretion of the hormone. |
| Permissiveness | a mechanism of hormone integration in which the presence of one hormone is required in order for another hormone to generate a response. |
| Push-pull mechanism | a mechanism of hormone integration in which one hormone increases a response and another hormone decreases it. |
| Radioimmunoassay | a technique for measuring concentrations of an antigen such as a hormone by using antibodies and radioactive substances |
| Reinforcement | a single hormone acting in different ways in different tissues to produce complementary effects. |
| Sensitivity | describes the ability of a cell or organ to respond to a signal in proportion to the intensity of that signal. |
| Set point | any one of a number of quantities (e.g. body weight, body temperature, hormone levels) which the body tries to keep at a particular value. |
| Synergism/Potentiation | two or more hormones act through separate but complementary pathways to enhance each other's actions. |
| Tachyphylaxis | a decrease in response to a drug through downregulation of receptors or neurotransmitters that facilitate the drug's effect on the body. |
| Threshold | the lowest amount or concentration of hormone that produces a measurable response. |
| Thyrotropes | special type of cells in the anterior pituitary that secrete thyrotropin (thyroid stimulating hormone, TSH). |
| Thyroxin | the main hormone produced by the thyroid gland that increases metabolic rate and regulates growth and development. |