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Neurological Disease
| Question | Answer |
|---|---|
| Chromosome number and locus of Parkinson's disease? | 4q21 |
| Chromosome number and locus of Huntington's disease? | 4p16 |
| Chromosome number of Alzheimer's disease? Type 1, 2, 3, 4 respectively? | 21, 19, 14, 1 |
| Chromosome number and locus of Charcot-Marie-Tooth disease? | 17p12 |
| Chromosome number and locus of Rett syndrome? | Xq28 |
| Chromosome number and locus of Amyotrophic Lateral Sclerosis? | 21q22 |
| Chromosome number and locus of Spinocerebellar Atrophy? | 6p23 |
| Affected gene and protein of Parkinson's disease? | SNCA gene, alpha-synuclein |
| Affected gene and protein of Huntington's disease? | IT-15 gene, Huntington protein |
| Affected gene and protein of Charcot-Marie-Tooth? | PMP22: peripheral myelin protein22 MPZ: Myelin protein zero Cx32: connexin32 |
| Affected gene and protein of Alzheimer's disease? | APP, ApoE, PSEN1, PSEN2, beta-amyloid protein |
| Which brain part is affected by Parkinson's disease? | substantia nigra |
| Which brain part is affected by Huntington's disease? | Caudate nucllei, puttaman, globun pallidus |
| Caudate nuclei, puttaman, globus pallidus together are called... | basal ganglia |
| Which brain part is affected by Alzheimer's disease? | hippocampus, cerebral cortex |
| What hippocampus controls? | memory and emotions |
| What cerebral cortex controls? | language and reasoning |
| For Alzheimer's disease, gene mutation causes accumulation of __________ outside of neurons. | amyloid plagues |
| For Alzheimer's disease, gene mutation causes accumulation of _______________ inside neurons. | neurofibrillary tangles |
| What is thought the neurofibrillary made of? | tau protein |
| What disease is this: tremor, muscle rigidity, slowed movement, affected substantia nigra, caused by decrease of dopamine and production of lewy bodies. | Parkinson's disease |
| What disease is this: intellectual decline, psychiatric changes, dementia, affected caudate nuclei, caused by altered protein and CAG repeat, secretion of GABA? | Huntingon's disease |
| Which disease is this: most common form of dementia and 4th leading cause of death in adults, irreversible progressive brain disorder, affected hippocampus and cerebral cortex, caused by accumulated amyloid plaques or neurofibrillary in brain | Alzheimer's disease |
| n of the muscle in the foot, leg, hand, drop foot walk, affected Schwann cells, caused by deletion/duplication of 17p12 causing demylination | Charcot-Marie-Tooth disease |
| Which disease is this: epilepsy, recurrent seizures, caused by mutation in the SPM2A gene, exceccive laforin protein destroys brain cell. | LaFora disease |
| Which disease is this: most common mental retardation in females, loss of use of hands and speech, brain size reduction, X-linked, lethal in males, mutated MeCP2 and BDNF gene disturbs brain development | Rett syndrome |
| Which disease is this: no muscle nourishment in the spinal cord area, progressive degeneration of motor neuron cells, mutated SOD1 cause cell death by free radicals | Amyotrophic Lateral Sclerosis (ALS) |
| Which disease is this: degeneration of the spinal cord and the cerebellum affects body movement, jerky and uncoordinated motions, caused by CAG repeat, lack of CAT sequences causing uninterrupted CAG over-producing glutamine which hurt cell | Spinocerebellar atrophy |
| Which disease is this: lipid storage disease, metabolic storage disease, form "foam cells", abdominal distention, severe neurodegeneration, feeding problems, blindness, enlarged liver and spleen, cherry red spot in the eye | Niemann Pick Disease |
| Which diseases are affected by CAG repeats? | Huntington's disease, Spinocerebellar atrophy |
| Which disease is affected by SNCA gene? | Parkinson's disease |
| Which disease is affected by formation of Lewy bodies? | Parkinson's disease |
| Which disease is affected by APP, APoE, PSEN genes? | Alzheimer's disease |
| Which disease is affected by CMT, Cx32 gene? | Carcot-Marie-Tooth disease |
| Which disease is affected by myelin protein 22? | Charcot-Marie-Tooth disease |
| Which cells are affected in Charcot-Marie-Tooth disese? | Schwann cells |
| Which disease is affected by EMP2A gene? | LaFora disease |
| Which disease is affected by MeCP2 gene? | Rett Syndrome |
| Which disease is affected by mutated SOD1 gene? | Amyotrophic Lateral Scleorosis (ALS) |
| Which part of body is affected by Amyotrophic Lateral Sclerosis (ALS)? | Motor neuron |
| Which disease is affected by abnormal SCA1 gene which over-produce glutamine? | Spinocerebellar atrophy |
Created by:
hiroko2013
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