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NSGSUX-SLE

QuestionAnswer
What is SLE? A multisystem inflammatory disease of autoimmune origin
Who is usually affected by SLE? Women in childbearing years esp African Americans, after menarche, with the use of oral contraceptives, and during and after pregnancy
What are the origins of SLE? interactions among genetic, hormonal, and immunologic factors
What is the etiology of SLE? unknown
When does SLE tend to worsen for women? after the immediate postpartum period
What are the most significant environmental triggers of SLE? sun exposure and sunburns
Which drugs aggravate SLE? procainamide (Pronestryl), hydralazine (Apresoline), and antiseizure drugs
What is SLE characterized by? production of a large variety of autoantibodies
What is the progressive pattern of manifestations in the progression of SLE? there are no specific patterns
Which organs can be affected by the accumulation of circulating immune complexes? any organ
What are the most commonly affected tissues in SLE? skin, muscle, lining of the lungs, the heart, nervous tissue, and kidneys
What are the generalized complaints of SLE that may precede disease activity? fever, weight loss, arthralgia, and excessive fatigue
What is subacute cutaneous lupus? Patients that have persistent lesions, photosensitivity, and mild systemic disease
What is the most common dermatologic manifestation of SLE? butterfly rash or malar rash
What are the dermatological manifestations of SLE? butterfly rash, persistent lesions, photosensitivity, ulcers, alopecia
What are the musculoskeletal manifestations of SLE? polyarthralgia with morning stiffness, arthritis, diffuse swelling, joint and muscle pain, deformities such as swan neck, ulnar deviation, and subluxation
What does tachypnea and cough in a patient with SLE suggest? restrictive lung disease
What are the cardiopulmonary manifestations of SLE?? tachypnea, cough, pleurisy, pleural effusion, dysrhythmias, pericarditis, hypertension, hypercholesterolemia, CAD
Why do people with SLE develop dysrhythmias? fibrosis of the SA and AV node
In which SLE patient is the likelyhood of developing CAD higher? those taking corticosteroids or those who have renal problems
What is the primary goal of treating lupus nephritis? slow the progression of neuropathy and preserve renal function by managing the underlying disease
What are the renal problems related to SLE? lupus nephritis, proteinuria, glomerulonephritis
Why would you consider obtaining a renal biopsy on an SLE patient? to guide renal treatment
Which drugs are given to treat renal problems in patients with SLE? corticosteroids, cytotoxic agents (cyclophosphamide or Cytoxan), and immunosuppressants such as azathioprine (Imuran) and cyclosporine (Sandimmune); oral prednisone, pulsed IV methylprednisolone, and mycophenolate mofetil (CellCept)
What are the neurologic manifestations of SLE? seizures, peripheral neuropathy, cognitive dysfunction, disordered thought process, disorientation, memory deficits, svere depression and psychoses, stroke, aseptic meningitis, headache
What are some of the hematological problems associated with SLE? anemia, leukopenia, thrombocytopenia
What is a major cause of death in those with SLE? infection
WHat is the most common infection in SLE patients? pneumonia
WHy do SLE patients have an increased risk for infection? defects in ability to phagocytize bacteria, deficient production of antibodies, immunosuppressant effects of antiinflammatory drugs
Which SLE patients should avoid vaccines? Those who wish to receive live virus vaccines who are being treated with corticosteroids or cytotoxic agents
Is fever serious for the SLE patient yes-may indicate underlying infection
Created by: tmorg581
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