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Carbohydrate metabol

HMP shunt

Functions of HMP shunt? 1)NADPH production 2)Source of ribose 5-phosphate for nucleotide synthesis
Thiamine pyrophosphate(TPP) requiring enzymes? pyruvate dehydrogenase,alpha-ketoglutarate dehydrogenase,branched chain ketoacid dehydrogenase,transketolase
Functions of NADPH? 1)biosynthesis(fatty acids,cholesterol,nucleotides) 2)Protection against ROS by maintaining supply of reduced glutathione 3)bactericidal activity in PMN 2)
Hallmarks of G6PD deficiency 1)Immunodeficiency 2)Heinz bodies 3)Hemolytic anemia
Enzyme defective in Chronic granulomatous disease NADPH oxidase in PMN
Wernicke Korsakoff disease Transketolase has reduced affinity for TPP
Created by: mistletoe



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