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Carbohydrate metabol
HMP shunt
Question | Answer |
---|---|
Functions of HMP shunt? | 1)NADPH production 2)Source of ribose 5-phosphate for nucleotide synthesis |
Thiamine pyrophosphate(TPP) requiring enzymes? | pyruvate dehydrogenase,alpha-ketoglutarate dehydrogenase,branched chain ketoacid dehydrogenase,transketolase |
Functions of NADPH? | 1)biosynthesis(fatty acids,cholesterol,nucleotides) 2)Protection against ROS by maintaining supply of reduced glutathione 3)bactericidal activity in PMN 2) |
Hallmarks of G6PD deficiency | 1)Immunodeficiency 2)Heinz bodies 3)Hemolytic anemia |
Enzyme defective in Chronic granulomatous disease | NADPH oxidase in PMN |
Wernicke Korsakoff disease | Transketolase has reduced affinity for TPP |