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MOLB Chapter 17

Adaptive Immunity

Adaptive Immunity 1. includes specialized lymphocytes (T&B cells) 2. includes antibodies
Pasteur injected chicken with weakened pathogen, fully virulent pathogen did not kill them
Von Behring showed bacteria could produce toxins, low levels of pathogen injected in rabbit, transfused blood into sick rabbit, lived
Ehrlich discovered that there was a 1:1 ratio of antitoxin to toxin
Agglutination antibodies clump together to ease phagocytosis
Opsonization antibodies bind to microbe to ease adhearance of phagocytes
Antibody dependent cell mediated cytotoxicity eukaryotic pathogen covered in antibodies immune cells release chemicals to lys cell
Neutralization antibody binds to receptor of intracellular pathogen and blocks cell from its normal receptor
Primary Response to pathogen 4-7 days to develop antibodies IGM, IGG, peak at 10-17 days after exposure
Secondary (memory or anamnestic) response Rapid, peaks at 2-7 days after exposure, increased amount of antibodies, lasts many days
TH1 Produce cytokines
TH2 produce cytokines to increase the # of antibodies made in an allergic response
TH17 produce cytokine 17 which in involved in inflammation response and pathogen protectionof extracellular
Follicular TH produce more B and plasma cells
T regulatory cells check T cells before release
APCS B cells, activated macrophages and dendritic cells, digest antigens,
Created by: 100000860991270