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Neoplasia.
neoplasia
| Question | Answer |
|---|---|
| What is Neoplasia? How are they different that Hyperplasia and repair? | IT is new tissue growth. It is different because- monoclonal, unregulated and irreversible(unlike hyperplasia) |
| What is monoclonality? | It is when ALL the cells are derived from a single mother cell |
| How would you determine monoclonality in female-androgen receptor isoform(male)? | there are dozens of isoforms of G6PD. baby girl from mom and dad. Inactivation of the X is random.(Ususally in 1:1 ratio)<= polyclonality In monoclonality= Look at g6pd for 1 type of isoform.(not 1:1 ratio) |
| How can you determine the clonality of B cells? | lymph node- light chain of immunoglobulins are either kappa or lamda is (3:1). In infection- hyperplasia(still ration 3:1).in neoplastic lymphoma(access of kappa) |
| Which tumors are monoclonal? | both benign nad malignant |
| Difference between benign and Malignanat tumours | Neoplastic tumors are benign or malignant. 1. Benign tumors remain localized and do not metastasize.(not true cancer cancer) 2. Malignant tumors (cancer) invade locally and have the potential to metastasize. |
| what are the four major tissues in the body ? | epithelium(line the gut, body), connective tissue(fat, blood vessel, cartilage), lyphocytes, melanocyte |
| Epithelim benign tumour | Adenoma |
| Epithelim malignant tumour | Adenocarcinoma |
| Epithelim benign tumour(papilary) | papiloma |
| Epithelim malignant tumour(papilary) | papilary carcinoma |
| What is meant when its a epithelium papilary tumor? | a projection of epitheliel cells with a base of connective tissue with an artery and vien in the center. |
| Mesenchymal benign tumour | lipoma(oma means mass) |
| Mesenchymal malignant tumour | Liposarcoma(sarcome means malignant tumour) |
| Lymphocyte benign tumour | NO exist |
| Lymphocyte malignant tumour | Lymphoma/ leukemia |
| Melanocyte benign and malignant tumour? | nevus and melanoma (oma means mass) |
| Screening:divisions before symptoms arize | single mutated cell goes 30 divisions before the earliest symptoms arize. |
| Screening:Cancers detected late have a poor prognisis? | Cancers that do not produce symptoms until very late: more divission more mutations |
| Screening: Goal of screening -2 | Catch dysplasia before it becomes cancerous detect carcinoma before clinical symptoms arize |
| Screening: Methods(pap smear, mammography, psa and Dre, Hemoccult test and colonoscopy) | -Pap smear- detects cervical dysplasia -Mammography- detects in situ breast cancer -Prostate specific antigen (PSA) and digital rectal exam- detects prostate carcinoma - Hemoccult test (occult bloody stool) and colonoscopy- detect colonic adeninoma |
Created by:
atayal
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