Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Didn't know it?
click below
Knew it?
click below
Don't know
Remaining cards (0)
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Immune Deficiencies

Female with increased IgE levels and eczema Job's hyper-IgE syndrome (Wiskott-Aldrich is x-linked, Job's is autosomal)
Male with increased IgE levels and eczema; normal platelet count Job's hyper-IgE syndrome
Patient with increased IgE levels and eczema; thrombocytopenic purpura Wiskott-Aldrich syndrome
Absence of thymic shadow on CXR; recurrent viral, bacterial, fungal, and protozoal infections Severe combined immunodeficiency (DiGeorge only has low T cells, SCID has low T & B cells)
Decreased IgA; recurrent sinopulmonary infections; increased risk of cancer Common variable immunodeficiency (this may present with any combination of deficient immunoglobulins)
X-linked CD40 ligand mutation; B cell defect Hyper-IgM syndrome
X-linked tyrosine kinase gene mutation; B cell defect Bruton's agammaglobulinemia
Severe pyogenic infections at young age; large quantities of a pentameric immunoglobulin in the serum; other immunoglobulin levels are decreased Hyper-IgM syndrome
Candida albica infections of skin and mucous membranes; T-cell dysfunction Chronic mucocutaneous candidiasis
Kinase defect leading to cerebellar problems, spider angiomas, and recurrent sinopulmonary infections Ataxia-telangiectasia
Defect in B-cell maturation; increased risk of comorbid autoimmune disease; labs show normal number of B cells, but low plasma cells Common variable immunodeficiency
Failure of 3rd and 4th pharyngeal pouches to develop DiGeorge syndrome
Most common primary antibody deficiency; patients may get sinus & lung infections, milk allergies, and diarrhea Selective IgA deficiency
Recurrent viral and fungal infections, hypocalcemia, velocardiofacial syndrome DiGeorge syndrome
Isotype switching defect; commonly occurs with celiac disease Selective IgA deficiency
22q11 deletion; absence of thymic shadow on CXR DiGeorge syndrome
IL-2 chemokine receptor mutation leading to recurrent viral, bacterial, fungal, and protozoal infections Severe combined immunodeficiency (x-linked form, which is more common)
Adenosine deaminase deficiency Severe combined immunodeficiency (autosomal recessive form)
ATM gene defect, which codes for DNA repair enzymes Ataxia-telangiectasia
Common gamma chain defect leading to a defective IL-7 receptor; failure to synthesize MHC-II antigens Severe combined immunodeficiency
Commonly occurs with tetralogy of Fallot or truncus arteriosus DiGeorge syndrome (mnemonic is "CATCH-22": Cardiac abnormalities, Abnormal facies, Thymic aplasia, Cleft palate, Hypocalcemia/Hypoparathyroidism, 22q11 deletion)
Normal pre-B cells in the bone marrow, but not in the periphery; recurrent bacterial infections after 6 months Bruton's agammaglobulinemia
Created by: kesselmb



Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards