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CA overview 1
Question | Answer |
---|---|
What are the different genes when talkin about CA? | protoocengenes-normal cell growth but proliferate beyond normal cell replication, antioncogenes-tumor suppressor genes, oncogenes-mutated genes that turn a normal cell into a CA cell |
Which ethnic group is more likely to die from CA? | African Americans |
Which racial group has the lowest rate of CA? | Mexican Americans but they have the highest rate of infectious causing CA (uterine, liver, stomach) |
Who has the highest rate of Kidney CA? | Native and Alaskan Americans |
What is the biggest concern for CA patients? | pain management |
What are the different type of CA prevention? | Primary-education, avoiding carcinogens Secondary- self exams, screenings Tertiary- responding to complications, disability or rehab |
What are the cardinal warning signs of CA? | "CAUTION" Change in bowel habits, A sore that won't heal, Unusual bleeding or discharge, Thickening in a lump or mass, Indigestion of difficulty swallowing, Obvious change in mole or wart, Nagging cough or hoarsness |
What is the name for the process which normal cells undergo malignant transformation? | carcinogenisis |
What is the initiation stage? | irreversible change in the genetic make-up, but doe not always lead to CA |
What are the CA related genes associated w breast CA? | BRCA1 and BRCA2 |
What viruses are associated w later causing CA? | HEP B&C, HIV, Epstien Barr, H.Pylori (infectious agent), HPV |
What is the promotion stage? | The reversible stage but if prevention isn't taken, there is an increase chance to become malignant |
What is the progression stage? | When malignancy occurs and invasiveness is enhanced. Tumor angiogenesis occurs during progression phase |
What is tumor angiogenesis? | When the tumor develops its own blood supply |
What is the general rule for differentiation? | The more differentiated, the less malignant, the less differentiated, the more malignant |
How does staging of CA work? | TNM T0-no tumor, T1-4 size, Tx-can not be assessed (treatment effective)Tis- in situ, |
What is the definitive test for diagnosis of CA? | biopsy |