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A Nursing Process Approach Chapter 1

Three phases of drug action for PO Drugs Pharmaceutic (dissolution), Pharmacokinetic, and Pharmacodynamic
Pharmaceutic Phase (Dissolution) is the first phase of drug action, has two phases known as disintegration and dissolution.
Disintegration the break down of a tablet into smaller particles
Dissolution the dissolving of the smaller particles in the GI Fluid before absorption.
Rate Limiting is the time it takes a particular drug to disintegrate and dissolve to become available for the body to absorb it.
Excipients Fillers used in tablets to allow for stability of drug or shaping of tablets.
Pharmacokinetics Phase is the process of drug movement to achieve drug action. Consists of 4 processes; absorption, distribution, metabolism, and excretion. This is the second phase in PO medications and the initial phase in parenteral drugs.
Absorption is the movement of drug particles from the GI tract to body fluids by passive absorption, active absorption, or pinocytosis.
First-Pass Effect Hepatic First Pass: metabolism by the liver from the hepatic portal vein after absorption from the lumen of the intestines.
Bioavailability is a subcategory of absorption. It is the percentage of the administered drug dose that reaches the systemic circulation.
Created by: aaron.streeter2