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GowFundsII
Chapter34 Drugs to treat disorders of Musculoskeletal System
| Question | Answer |
|---|---|
| RA- Rheumatoid Arthritis | chronic inflammation of connective tissue |
| Osteoarthritis | Non-inflammatory degeneration so articular cartilage and change in the synovial membrane |
| Bone resorption inhibitors | bisphosphonates |
| Bone resorption inhibitors USE | Osteoporosis in post menopausal women and men. hypercalcemia of malignant disease and Paget's disease of the bone |
| Examples of Bone resorption inhibitors | Fosamax, Boniva, Actonel |
| Adverse Reactions of Bone resorption inhibitors | Nausea diarrhea, acid regurgitation, increased or recurrnet back pain, dyspepsia |
| Adminstration guidelines for bone inhibitors | empty stomach, have to sit up for 30 minutes |
| Bone resprtion inhibitors contraindication | delayed esophageal emptying or renal impairment & hypersenstivey |
| DMARD | For Rheumatoid Arthritis-sulfa based drug |
| Adverse Reaction DMARD | Nausea, stomatitis, alopecia, |
| Methotrexate | watch for bruising (thrombocytopenia) Infection (leucopenia) |
| Examples of DMARD | Plaquenil, Remicade, Enbrel, Imuran, Cytoxan, Humira |
| Gold is the last result! Watch for what? | mouth ulcers, Give good oral care! |
| Uric acid inhibitors | Managing and preventing acute attacks of gout |
| Gout | A form of arthritis in which uric acid accumulates in the blood and is often deposited in the joints |
| Adverse Reactions of Uric Acid Inhibitors | GI reactions N/V & diarrhea |
| Zyloprim (allopurinal) | Reduces uric acid production (chronic use) |
| Cholchicine | Reduces inflammation for acute attacks |
| Probenicid | Prolong plasma levels of penicillin |
| Adminstration Guidelines for Uric Acid inhibitors | With meals/food or immediately after eating |
| Crystralluria | Crystals in urine |
| What to watch for with crystalluria | kidney stones |
| pts with crystalluria should? | drink 1000-2000ml of fluids a day |
| Skeletal Muscle Relaxants | Use:various acute painful muscle spasm, lumbar strains, cervical strain, neck back pain |
| Adverse Reaction of Skeletal Muscle Relaxants | #1 is drowsiness |
| Flexeril | (cyclobenzaprine |
| Valium | causes Drowsiness, sedation, |
| Be careful with MAOI use. Why? | Can excatrabate Psychosis |
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