Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
med immunology 17
Immunodeficiency disorders & neoplasias of the lymphoid system
| Question | Answer |
|---|---|
| Which immunodeficiency is this: hereditary or acquired, may involve abnormal cytokine/chemokine receptors, T-cell mediated, B-cell mediated, B&T cell mediated, nonspecific mediation by phagocytes/NK cells, complement activated | primary immunodeficiency |
| which immunodeficiency is this: result of other conditions/diseases/infections (malnutrition, chemotherapy side effect, untreated autoimmunity, HIV or other viruses) | secondary immunodeficiency |
| DiGeorge Syndrome is which type of immunodeficiency? | Primary |
| SCID (severe combined immunodeficiency) is which type of immunodeficiency? | primary |
| Frequency of primary immunodeficiency is _____ within the population. Usually due to a problem in ___________ __________ ____. | rare, development of immune cells |
| The earlier primary immunodeficiency occurs, the _____ severe the impact on immune response but ________ opportunity for redundancy | more, reduces |
| secondary immunodeficiencies can also occur by the introduction of __________ drugs used in transplantation. | immunosuppressive |
| what are two causes of SCID? | X-linked: missing gamma chain(cytokine receptors ) Autosomal: missing JAK3 tyrosine kinase |
| What causes bare lymphocyte syndrome? | missing MHC classII |
| what causes ALPS (autoimmune lymphoproliferative syndrome)? | missing Fas (cell membrane determinants) |
| what causes Hyper IgM syndrome? | missing CD40L (cell membrane determinants) |
| what is the other name of Chronic granulomatous disease (CGD)? | Bridges-Good syndrome |
| CGD is a diverse group of hereditary diseases in which phagocytes have difficulty forming the _______ ______ ________ used to kill ingested pathogens by repiratory burst and oxidation. | reactive oxygen compounds |
| Because CGD patients' phagocytes cannot kill ingested pathogens by oxidation, it leads to the formation of _________ in many organs. | granuloma |
| CGD affects about 1 in __________people in the USA. | 20,0000 |
| _________ ________ is a rare autosomal recessive disorder that arises from microtubule polymerization defect in the cytoskelton which leads to decrease in _________ _________. | Chediak-Higashi syndrome, phagocytosis ability |
| What are 3 phases of HIV infection? | acute phase, chronic(latent)phase, crisis phase |
| At initial infection of HIV, __________ decrease | CD4+T cells |
| At initial infection of HIV, CD4+T cells _________ because infected T cells are more prone to lysis(apoptosis) by CTLs(cytotoxic T lymphosites). | decrease |
| During many years of Chronic(latent) phase of HIV infection, what factors lead patients to crucial immunodeficiency level? | gradual decline of CD4+T cells with low level of viral replication |
| At chronic phase of HIV infection, most of the infected cells are localized to ______ ______. | lymph nodes |
| Healthy individuals have CD4+:CD8+ T cells ratio of ________. | 2:1 |
| At chronic phase of HIV infection, which T cells, CD4+T or CD8+T, outnumber which T cell? | CD8+T cells outnumber CD4+T cells |
| At crisis phase of HIV infection, CD4+T cell count drops below ______ cells/uL or less than _____ % of T cell population. | 200, 14 |
| At crisis phase of HIV infection, the patient develop unusual _______, _________, __________. | malignancies, opportunistic infections, general debilitating syndromes(immune system and CNS dysfunction) |
| what is called abnormal cell proliferation? | neoplasias |
| Neoplasias is uncontrolled _______ proliferation that can be related to their normal cell counterparts by surface markers and stage of differentiation. | monoclonal |
| Many neoplasias have ______ _______ causing disregulation of cell proliferation and death. | chromosomal translocations |
| What is this disease: malignant cells of the circulatory system, proliferation of immature WBCs ? | leukemias |
Created by:
hiroko lucky2
Popular Biology sets