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med immunology 16
Hypersensitivity Type 4
| Question | Answer |
|---|---|
| What kind of hypersensitivity is type IV hypersensitivity? | delayed or cell mediated |
| How and when does inflammation occurs in type IV hypersensitivity? | it occurs due to contact with certain antigens after 2-3 days of contact |
| Type IV hypersensitivity is resulted from the interactions of antigen, __________, and _______. | APCs, T cells |
| Why type IV hypersensitivity response is delayed? | Because it takes time for macrophages and T cells to migrate to and proliferate at the site of the antigen. |
| Unlike the other types, type IV hypersensitivity is a ______- mediated response that involves ______. | cell, T cells |
| List examples of type IV hypersensitivity | Tuberculin response, allergic contact dermatitis, graft rejection, graft versus host disease |
| what kind of cells are involved in tuberculin responses? | lymphocytes, monocytes, macrophages |
| If T-cell function is abnormal, the patient presents with _________ infections. | opportunistic |
| What are the causes of infections for the patient who has type IV hypersensitivity? | infection with mycobacteria, fungi, parasites, mucocutaneous candidiasis, Crohn's disease |
| Which disease is this: also known as regional enteritis | Crohn's disease |
| Which disease is this: a type of inflammatory bowel disease that may affect any part of the gastrointestinal tract from mouth to anus, causing a wide variety of symptoms | Crohn's disease |
| which disease is this: caused by interactions between environmental, immunological, and bacterial factors in genetically susceptible individuals resulting in a chronic inflammatory disorder. | Crohn's disease |
| Crohn's disease results in a chronic inflammatory disorder, in which the body's immune system attacks the _____________ possibly directed at microbial antigens. | gastrointestinal tract |
| Crohn's disease has traditionally been described as an autoimmune disease, but recent investigators have described it as a disease of _____ ________. | immune deficiency |
| Which is more likely affected by Crohn's disease, males or females? | both are equally affected |
| Who are two times more likely to develop Crohn's disease? | smokers than nonsmokers |
| which disease is this: TH1 cells and APCs produce glutamate and it injures oligodendroglial cells of the central nervous system and underlying axons resulting in paralysis | Multiple sclerosis |
| In multiple sclerosis, which cells produce toxic substance? | TH1 cells and APCs |
| Which disease is this: about 1% of world's population is affected, women are three times more often affected, most frequent between age 40 and 50 | Rheumatoid arthritis |
| which disease is this: inflammation of the thyroid gland, autoimmune disease tends to occur in families, associated with other autoimmune conditions(Type1 diabetes,celiac disease), 5-10 times more common in women | Hashimoto's thyroiditis |
| What are two types of contact dermatitis? | irritant dermatitis, allergic contact dermatitis |
| Which type of contact dermatitis: most common type, caused by contact with acids, alkaline materials(soaps,fabric softners), reaction looks like a burn. | irritant dermatitis |
| which type of contact dermatitis: caused by exposure to a substance or material to which you have become extra sensitive or allergic | allergic contact dermatitis |
| Graft rejection is a normal immune response against foreign _____ _________ _______ proteins on the surface of ____ cells. | major histocompatibility complex (MHC), graft |
| how does it call graft between self? | autograft |
| how does it call graft between genetically identical sibling or clone? | isograft |
| how does it call graft between genetically different member of same species? | allograft |
| how does it call graft between different species? | xenograft |
Created by:
hiroko lucky2
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