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Bone Formation Cells

Osteoclasts, osteoblasts, osteocytes

Description/ FunctionCell Type
Break down - cells required for bone resorption. Osteoclasts
Maintainence of bone matrix. Osteocytes
Mononucleate cells derived from osteo-progenitor cells Osteoblasts
Form type 1 collagen, proteoglycans, glycoproteins. Osteoblasts
Located on the surface of mineralised bone or the osteoid. Osteoblasts
Formed from osteoblasts trapped in mineralised bone. Osteocytes
Occupy spaces called lacunae Osteocytes
May form chains of up to 15 linked cells using gap junctions to exchange nutritients and waste products. Osteocytes
Involved in calcium homeostasis Osteocytes
Large, multinucleate cells Osteoclasts
Located on surfaces of mineralised bone in Howship's lacunae (cavities) Osteoclasts
Control bone remodelling Osteoclasts
Release collagenases and protons that demineralise bone Osteoclasts
Have receptors for calcitonin Osteoclasts
Action results in release of calcium from bone into plasma Osteoclasts
Formed from fusion of marrow-derived cells Osteoclasts
Lay down a protein-based matrix which subsequently becomes calcified (osteoid) Osteoblasts
Protein- based matrix consisting of collagen, proteoglycans, and glycoproteins. Osteoid
Cuboidal shaped when activated Flat when inactive Osteoblasts
"Builders" - bone-forming cells. Osteoblasts
Created by: Kingfisher
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