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Pathophys-Immuno
Ch.15 Pathophysiology
Question | Answer |
---|---|
Myeloid lineage phagocytes | Derived from myeloid stem cells Monocytes Granulocytes Dendritic cells |
Dendritic cells | Found in epithelial tissues |
Granulocytes | Neutrophils (innate immunity), eosinophils & basophils (allergic reactions & anti-parasites) |
Monocytes | Found in most tissues, mature into macophages, central to adaptive immunity |
eosinophils & basophils | allergic reactions & anti-parasite |
Lymphoid lineage lymphocytes & natural killer cells | Derived from lymphoid stem cells B cells T Cells NK Cells |
B cells | recognize circulating antigens → produce antibodies |
T cells | recognize antigen bound to MHCs on antigen presenting cells (APCs) T helper cells Cytotoxic T cells |
T helper cells | CD4 |
Cytotoxic T cells | CD8 |
Natural killer (NK) cells | Innate immune cells Recognize tumor & virus-infected cells |
Central lymphoid tissues | Bone marrow & thymus Tissues where immune cells produced & mature |
T cells produced in ______ | marrow → migrate to thymus → proliferate & mature |
Thymic selection | only T cells that recognized foreign (not self) antigens survive Thymus regresses after puberty |
B cells produced in ______ | marrow and mature there – also undergo selection |
Peripheral lymphoid tissues | Lymph nodes |
Lymph nodes | located where lymph vessels converge Abundant in axiallae, groin, abdomen flows through nodes bringing antigens |
Antigen presenting cells exposed to antigens _____ | → activate T cells |
T cells activated in the ____ | paracortex → proliferate → migrate to cortex |
B cells in follicles of _____ | cortex activated → move to medulla |
B cells mature in | medulla → release Antibodies |
Spleen | in abdominal cavity Filters antigens – Acts as huge lymph node |
Other secondary lymphoid tissues | Clusters of lymphoid tissue MALT – mucosa associated lymph tissue Membranes of GI, respiratory, GU tracts Peyers patches - intestines |
General purpose cytokines | Chemicals produced by immune cells Bind to receptors on nearby cells Contribute to a variety of parts of the immune response |
Chemokines | Similar to cytokines Stimulate migration & activation of immune cells Implicated in arthrosclerosis, Crohn disease, asthma, etc |
Colony stimulating factors | Stimulate blood cell production in marrow |
Epithelial barriers | Innate Immunity Skin Mucous membranes |
Skin | excellent barrier & also has antibacterials (Lysozyme) |
Mucous membranes | Mucus traps microbes → cilia remove them GI, GU, Respiratory |
Lung | Collectin proteins (surfactants) target pathogens for phagocytosis |
Stomach | Defensin proteins kill bacteria by disrupting membrane |
Cells of innate immunity | Phagocytes engulf & destroy bacteria Neutrophils Macrophages Dendritic cells NK cells |
Macrophages | later-responding phagocytes |
Dendritic cells | antigen presenting cells Link innate & adaptive immune responses |
NK cells | Lymphocytes Recognize virus-infected & cancer cells → kill them Have activation receptor – recognizes abnormal surface antigens Have inhibitory receptor - recognizes self antigens If both engage → NK cell takes not action Cytokines induce apoptosis |
Neutrophils | early-responding phagocytes |