Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
med immunology 14
Hypersensitivity Type 1
| Question | Answer |
|---|---|
| What is hypersensitivity? | any immune response against a foreign antigen that is exaggerated beyond the norm |
| List four types of hypersensitivity | Type I,II, III, IV |
| which type is immediate? | type I |
| which type is cytotoxic? | type II |
| Which type is immune-complex mediated? | type III |
| which type is delayed or cell-mediated? | type IV |
| Is type I hypersensitivity localized or systemic reactions that result from the release of inflammatory molecules in response to an antigen? | both |
| Which type of hypersensitivity: develop within seconds or minutes following exposure to an antigen, commonly called allergies and the antigens that stimulate them are called allergens | typeI |
| what are two stages of type I hypersensitivity? | sensitization, degranulation |
| Among cells involved in Type I hypersensitivity, what cells are found in sites close to body surfaces such as the skin and the walls of the intestine, whose cytoplasm is filled with large granules which contain a mixture of potent inflammatory chemicals? | mast cells |
| Type I hypersensitivity is commonly called _______ and involves ________ antibodies. | allergies, IgE |
| Antigens that stimulate Type I hypersensitivity are called ______. | allergens |
| In sensitization phase, APC _________ allergen and presents to _______ cell, the cell secretes ____ to stimulate ____ cell which secretes IgE, then IgE binds to ____ cells, ______, and _______. | phagocytizes, TH2, IL4, B, Mast cell, Basophil, Eosinophil |
| What do mast cells contain in its cytoplasm? | large granules containing a mixture of potent inflammatory chemicals |
| Among cells involved in Type I hypersensitivity, what cells are leukocytes which can be stained with basophilic dyes and contain granules filled with inflammatory chemicals? | Basophils |
| Among cells involved in Type I hypersensitivity, what cells are leukocytes that can be stained with the dye eosin and contain inflammatory mediators and leukotriens that contribute to the seerity of a hypersensitivity resonse? | Eosinophils |
| Among cells involved in Type I hypersensitivity, what cells are mainly involved? | mast cells |
| Among cells involved in Type I hypersensitivity, what cells take care of worms? | eosinophils |
| What phenomena stimulates the release of eosinophis to migrate to the site where is occuring? | mast cell degranulation |
| Which inflammatory molecule is this: released during degranulation and causes smooth muscle contraction, increased vascular permeability, and irritation? | histamine |
| which inflammatory molecules is this: relased during degranulation, cause smooth muscle contraction, inflammation and irritation? | Kinins |
| Which inflammatory molecules is this: released during degranulation, damage tissues and activate complement? | proteases |
| What inflammatory molecules released from mast cells during degranulation? | histamin, kinins, proteases |
| Which inflammatory molecule is this: synthesized in response to inflammation, cause slow, prolonged smooth muscle contraction? | leukotrienes |
| Which inflammatory molecule is this: synthesized in response to inflammation, some contract smooth muscle, others relax it? | prostaglandins |
| Which inflammatory molecules are synthesized in response to inflammation? | leukotrienes, prostaglandins |
| In type I hypersensitivity, what causes systemic allergic reactions? | degranulation of many mast cells at once |
| why degranulation of many mast cells at once cause systemic allergic reactions? | it causes the release of large amounts of histamine and inflammatory mediators. |
| Degranulation of many mast cells at once cuases ______ ________ or _________ which results suffocation. | acute anaphylaxis, anaphylactic shock |
| When suffocation from anaphylactic shock happens, bronchial smooth muscle _____ violently, leakage of fluid from blood vessels causes ______ of the larynx and other tissues, the smooth muscle of the intestines and bladder ________. | contracts, swelling, contracts |
| To treat type I hypersensitivity, drugs that ________ the inflammatory mediators released by degranulation are administered. | counteract |
| What drug can counteract and neutralize histamine? | antihistamine |
| How can asthma be treated? | with an inhalant containing corticosteroid and a bronchodilator |
| What does quickly neutralize many of the mechanisms of anaphylaxis? | epinephrine |
| Epinephrine _____ smooth muscle and reduce _______ ________. | relax, vascular permeability |
| Which drug can be used for emergency treatment of severe asthma and anaphylactic shock? | epinephrine |
| When worm antigens are detected by mast cell, mast cell secretes ______ and ________, and it makes _________ migrate where the worm is to attack. | histamine, eoshinophil chemostatic factor, eosinophils |
Created by:
hiroko lucky2
Popular Biology sets