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RA

QuestionAnswer
Define RA chronic, progressive, autoimmune disorder that affects the connective tissues in the synovoal joints
What makes RA an autoimmune disorder? the development of autoantibodies (Rhuematoid factor)
Which gender is RA more prevalent? women
What are other theories as to why RA occurs? smoking, human leukocyte antigen (HLA-DR4)
How is RA diagnosed? morning stiffness that lasts for more than 1h, symmetrical joint swelling in 3 or more joints (especially in the hands, erosion/decalcification on XRAY, +RF, rheumatoid nodules, increased ESR, increased C reactive protein
What is the preferred diagnosis between Xray and bone scan? bone scan, xray will only show in later stages
What type of meds do PTs w RA usually take? DMARDs (methotrexate, gold compounds)
What is the con to taking DMARDs? Bone marrow suppression, hepatoxicity, needs freq CBC and Chem 7
What type of drugs can be given instead of DMARDS? biological agents (enebrel, remicade, orencia, Humira)
When is apheresis (prosorba column) used? When PT does nto resond to DMARDs. TX is for 12 wekks 1-2 times a week to remove RF from blood
Why are splints used in RA? to prevent deformities and for rest of an inflamed joint, make sure to remove regularly for skin care and ROM
What is the baseline TX for RA? Methotrexate
When should RA be treated? Within the first 1-6 months to decrease severity, however systemic complications remain the same hence the mortality rate is the same
What are the manifestations of Sjogren's syndrome? decreased lacrimal and salivary gland secretion (dry mouth, itchy eyes) photo-sensitivity
Which PTs are more prone to Felty's syndrome? Those with nodular forming RA
What are the manifestations of Felty's syndrome? splenomeagaly, inflammatory eye disorder, lymphadeopathy, pulmonary dz, blood dyscrasis
Created by: brebre273