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med immunology 8

role of MHC

QuestionAnswer
T cell response is ___________ dependent (restricted) antigen
T cell response is facilitated by __________. MHC receptor molecules
MHC receptors are located on the __________ of all ________ or _________. surface membrane, nucleated cells, APC presenting cells
APCs ingest _______ antigens by _________. protein, phagocytosis
After APCs digest protein antigens into simple peptides, they bind to _________ that are located on the surface of APCs. MHC receptors
MHC molecules present these processed antigens to _________ that have appropriate receptors. T-cells
List 2 different sets of T cells which respond to 2 different sets of MHC receptors. CD4+T cell responds to MHC2 CD8+T cell responds to MHC1
MHCs are complex proteins coded by a family of genes, ______, that are inherited as a unit. haplotype
MHC proteins are __________ proteins that are embedded into cell membranes. transmembrane (integral)
MHC I is expressed on ___________, MHC class II is expressed on ________. all nucleated cells, APCs such as macrophages, B cells and dendritic cells
CD4+T cells can interact with _______ because it can express _______. APCs, MHC II
CD8+T cells can interact with __________ because it can express _______. any nucleated cells, MHC I
After CD4+T cell interacts with APCs, it ___________. synthesizes Cytokine like IL2
After CD8+T cell interacts with any nucleated cells, it _________. Kills infected cells
Viruses and cancer cells can _________ the expression of ______ and prevents it activating ______ that can act against the virus or the cancer cells. supress, MHC, specific T cell
When viruses and cancer cells suppress the expression of MHC and prevent from activating specific T cells, the mechanism makes the patient __________ which can lead to secondary infections by other pathogens. immune compromised
MHC I molecules bind catabolized __________like viruses, small bacteria, in the cell. endogenous antigen
MHC I is synthesized inside _________. endoplasmic reticulum
MHC II molecules bind catabolized __________antigens (majority of bacteria). exogenous
Dendritic cells also process _________ antigens but bind to MHC ___ molecules, and presents the antigens to CD8+T-cells. exogenous, I
MHC ___ interacts with ___________ receptor and prevents them from attacking and killing normal cells. I, natural killer cell
NK cells target only _________ cells and ______ cells. virus infected cells, tumor
MHC I do bind the peptides from normal self antigen but does not __________, because self molecules do not generate the __________. lead to T cell activation, second signal molecule (costimulator)
What is required to activate the uncommitted(naive)T cells, which is generated by binding of MHC I and nonself antigen? second signal molecule (costimulator)
What MHC genes are called? HLA (Human Leukocyte Antigen)
List the characteristics of HLA gene Those are haplotype of genes, Codominant, and the most polymorphic and most diverse in the human geneome.
MHC class I is coded by ___ independent regions on chromosome ___, and they are called _______,_______,_______. 3, 6, HLA-A, HLA-B, HLA-Cw
Because both _______ and ______ MHC proteins are fully expressed in each cell in each person, ___ different MHC molecules per cell per person will be made if all the geneotypes are heterozygous. maternal, paternal,12
What makes tremendous polymorphism and diversity at MHC class I? allelic combination of 3 gene systems
MHC class II is coded by ___ independent gene systems, and they are called _______, ______, and ______. 3, HLA-DP, HLA-DQ, HLA-DR
What is the difference of independent gene systems of MHC I and MHC II? HLA-DP,DQ,DR have A allele and B allele, but HLA-A,B,C don't.
Created by: hiroko lucky2
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