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Pharm2FinalXCV
| Term | Definition |
|---|---|
| LSD | Hallucinogen Lysergic Diethylamide Extremely potent-25-500mcg dose Initial effects-giddy start in 30min-2hr Psychogenic, 1-3hrs |
| Psilocin | Hallucinogen Like LSD but in mushrooms. |
| Bufotenin | Hallucinogen Toad Licking |
| Mescaline | Hallucinogen Found in cactus |
| MDMA | Hallucinogen And stimulant |
| Ibogaine | Hallucinogen Powerful-found in tabernathe african shrub May suppress heroin craving |
| Phencyclidine | PCP hyperfelxia and vertical nystagmus when overdosed |
| Riluzole | ALS Lou gherigs disease. orphan drug |
| N2O gas | GA MAC 105, cant put to sleep, sedation at 30%. Can change BP, dental anesthetic |
| Enflurane | GA contraindicated for epileptics May cause seizures |
| Isoflurane | GA Lowers bp Vasodialation |
| Desflurane | GA Irritating Gas, cough Must use IV GA |
| Sevoflurane | GA 99% eliminated through the lungs |
| MAC | Concentration of inhaled gas needed to work in 50% of patients |
| Propofol | IV GA Rapid acting, <1min Maybe Killed MJ Most common agent in US |
| Etomidate | IV GA |
| Ketamine | IV GA Profound analgesia, used in battlefield Emergence delirium increase BP decrease ventilation, bronchodialator |
| GA Adjuncts | Midazolam, pre op sedation and amnesia Opioids Fentanyl- complete incapacitation Dexmedeomidine- a2 agonist, sedates |
| Dantrolene | Treats Malignant Hyperthermia Muscles contract since rayonidine channels wont close. produces heat (108) and kills people. inhibits ryanodine receptors |
| Rocuronium | NMJ Blocker Rapid acting, 1-2min relaxe laranx and jaw for intubation |
| Atracurium | NMJ Blocker not metabolized by enzymes, good for ppl with liver/renal failure |
| Succinylcholine | NMJ Blocker opens NA channels and keeps them open causes fasiculations used for intubation |
| Epinephrine | Increases LA effects |
| Lidocaine | Amide LA Most widely used infiltration, nerve bock, epidural |
| Bupivacaine | Amide LA Longer duration of action Used during labor cardiotoxic if iv |
| Ropivacaine | Amide LA least motor effect. Useful in labor |
| Articane | Amide LA rapidly metabolized LA of choice for dentists |
| Benzocaine | Ester LA topical only |
| Cocaine Hydrochloride | Ester LA vasoconstrictive effects. |
| Reloxifene | SERM Estrogen agonist in bone to treat osteoporosis can cause thromboembolism and vasomotor symptoms |
| Clomiphene Citrate | Estrogen antagonist Induces ovulation in infertile women. Promotes FSH and LH |
| Leuprolide | GnRH Agonist treats androgen dependent prostate cancer, endometriosis, precocious puberty |
| Gonadotropins, menotropins | Increase fertility Spermatogenesis and ovulation |
| Oxytocin | Stimulates uterine contraction, milk release bonds to its receptor and causes calcium release in myometrial smooth muscle Estrogen increases oxytocin receptors |
| Dinoprostone | Prostaglandin for inducing pregnancy ripens uterus |
| Carboprost | Treats postpartum bleeding and can induce abortion in 2nd trimester |
| Misoprostol | Can terminate pregnancy with antiprogestin |
| Ergot Alkyloids | Cause strong uterine contractions Not used to induce labor, could kill the child Treats hemoraging |
| Terbutaline sulfate | B2 agonist stops uterine contractions increases cAMP not for diabetics receptors rapidly desensitize |
| Indomethicin | Stops prostaglandin synthesis |
| Mechlorethamine | Anti-cancer alkylizes N7 position on guanine, damages DNA in proliferative cells. Made from mustard gas, earliest agent |
| Cyclophosphamide | Alkylizing agent Longer half life than mustard drug immunosupressive treats wider range of cancers |
| Carmustine | Alkylating agent Nitrosourea Can treat brain tumors lipid soluble |
| Cisplatine | Alkylating Agent Platinum compound |
| Methotrexate | Antimetabolite S phase Inhibits dihydrofolate reductase Blocks ability to make deoxyuridylate and thymidylate Leucovorin bipasses need for this and protects normal cells. Also for psoriasis and RA |
| Mercaptopurine | Antimetabolite inhibits purine sythesis S phase metabolized by xanthium oxidase which is inhibited by allopurinol |
| Dox/Daunorubicin | Natural Anticancer come from streptomyces bind to DNA via intercalation Uncoil DNA Can cause CARDIOMYOPATHYYYYYYYy |
| Vinblastine/Vincristine | Natural Anticancer M phase specific disrupt mitotic spindle |
| Etoposide | Natural Anticancer Breaks DNA, G2 phase Semisynthetic podophyllotoxin FOR THE NUT |
| Dexamethasone/Prednisone | Anticancer steroids suppresses mitosis Cushing's syndrome |
| Tamoxifen | Hormonal anticancer Antiestrogen for ER positive breast cancer male breast cancer Causes menopasal symptoms |
| Imatinib Mesylte | Inhibits tyrosine kinase in BCR-Abl positive leukemia cells |
| Trastuzumab | anitbody for da boobeez. EGF |
Created by:
amarche1
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