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Bio Chapter 6
Test 2
| Question | Answer |
|---|---|
| tumor | mass of cells with no function |
| metastatic cells can travel throughout the body via the.. | circulatory system or the lymphatic system |
| lymphatic system | collects fluid that leaks from capillaries |
| cancer cells differ from normal cells... | 1) they divide when they shouldn't 2) invade surrounding tissues 3) move to other locations in the body |
| risk factors for cancer | tabacco/alcohol use |
| asexual reproduction | -offspring are identical to the original cell or organism -involves inheritance of all genes from one parent |
| sexual reproduction | -offspring are similar to parents, but show variations in traits -involves inheritance of unique sets of genes from two parents |
| duplicated chromosomes are held together at the: and are called: | centromere sister chromatids |
| chromatin | DNA wraps around histone proteins |
| semiconservative replication | two identical daughter molecules, each with one parental strand and one new strand |
| DNA polymerase | the enzyme that replicates DNA |
| mitosis | the division of the genetic material in the nucleus |
| cytokinesis | the division of the cytoplasm |
| meiosis | gametes are produced by a variation of the cell division |
| meiosis yeilds: | nonidentical daughter cells that have only one set of chromosomes, half as many as the parent cell |
| three stages of the cell cycle | 1)interphase 2)mitotic phase 3)cytokinesis |
| mitotic spindle | composed of microtubules produced by centrosomes |
| centrosomes | structures in the cytoplasm that: -organize microtuble arrangement -contain a pair of centrioles in animal cells |
| aster | a radial array of short microtubules that extends from each centrosome |
| mitosis | -prophase -metaphase -anaphase -telophase |
| cytokinesis | division into separate cells |
| mutation | change in the sequence of DNA |
| proto-oncogenes | genes that enable cells to regulate cell division |
| oncogenes | normal proto-oncogenes that have mutated |
| tumor suppressor genes | genes for proteins that stop cell division if conditions are not favorable |
| angiogenesis | tumor gets it's own blood supply |
| contact inhibition | cells do not like to pile on each other |
| anchorage dependence | loss of this enables a cancer cell to move to another location |
| immortalized | cells no longer have a fixed number of cell divisions |
| multiple hit model | process of cancer development requires multiple mutations |
| biopsy | surgical removal of cells or fluid for analysis |
| needle biopsy | removal is made using a needle |
| laparascope | surgical instrument with a light, camera, and a small scalpel |
| chemotherapy | drugs that selectively kill dividing cells |
| radiation therapy | use of high-energy particles to destroy cancer cells |
| clone | a group of genetically identical individuals from the same parent |
| somatic cell | any cell other than a gamete |
| humans have __ pairs of chromosomes | 23 |
| __ pairs of autosomes | 22 |
| __ pair of sex chromosomes | 1 |
| locus | position of a gene |
| meiosis | a specialized form of cell division in gonads to produce gametes |
| gametes are: somatic cells are: | haploid diploid |
| meiosis beings with | interphase |
| recombinant chromosomes | combine DNA inherited from each parent |
| chiasma | the site of attachment and crossing over |
| random alignment | each pair of chromosomes sorts maternal and paternal homologues into daughter cells independently of the other pairs |
| nondisjunction | failure of chromosomes or chromatids to separate during meiosis |
| trisomy 21 | involves the inheritance of three copies of chromosome 21 |
| Adults produce ____ in their ____ by _____ | gametes, gonads, meiosis |
| Zygote | sperm cells fertilize egg cells to form single-celled zygotes |
| embryo | formed by repeated cell divisions |
| fetus | what the embryo grows into |
| genes | segments of DNA that code for proteins, analogous to words in an instruction manual for building a human |
| chromosomes | analogous to pages in the instruction manual |
| mutations | mistakes in copying DNA |
| alleles | different versions of genes |
| segregation | in meiosis, one member of each homologous pair goes into a gamete |
| independent assortment | randomly determines which member of a pair of chromosomes goes into a gamete |
| random fertilization | produces more diversity: 64 trillion possibilities! |
| monozygotic twins | only two humans that are genetically identical |
| phenotype | physical traits of an individual |
| genotype | description of the alleles for a particular gene in an individual |
| homozygous | both alleles for a gene are identical |
| heterozygous | the gene has two different alleles |
| recessive | the phenotype of an allele is seen only when homozygous |
| dominant | the phenotype is seen when homozygous or heterozygous |
| cystic fibrosis | a recessive human genetic disease |
| heritability | proportion of the variation within a population due to genetic differences among individuals |
| mean | sum up all the phenotypic values and divide by the number of individuals, same as average |
| variance | a measure of how much variability there is in the population |
| polygenic traits | quantitative traits with continuous variation |
| polygenic inheritance | skin color is affected by at least three genes |
| artificial selection | ex. only the cow giving the most milk was allowed to breed |
| high heritability | likely to be inherited |
| natural experiments | situations in which either the overlap in genes or environment is removed |
| incomplete dominance | two copies of the dominant allele are required to see the full phenotype |
| codominance | neither allele is dominant to the other; heterozygote shows both traits at once |
| multiple allelism | more than two alleles found in the population |
| Rh factor (completely dominant) | positive: you have Rh factor negative: you do not have Rh factor |
| pleiotropy | one gene influencing many characteristics |
| hemophilia | the inability to clot blood normally due to the absence of a clotting factor |
| sex-linked genes | genes located on the sex chromosomes |
| X-linked | located on the X chromosome |
| Y-linked | located on the Y chromosome |
| X-linked recessive traits | only females can be carriers of |
| Barr body | early female embryos randomly inactivate one of the X chromosomes in each cell |
| pedigree | reveals modes of inheritance |
| PCR | polymerase chain reaction in DNA fingerprinting |
| how to fingerprint DNA | DNA is mixed with nucleotides, specific primers, Taq polymerase, and then is heated |
| restriction enzymes | what DNA is cut into fragments using |
| VNTR (variable number tandem repeats) | cut around DNA sequences |
| gel electrophoresis | separates DNA fragments on basis of their sizes |
| agarose gel | electric current is applied to |
| probs | reveal locations of fragments containing VNTRs |