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USMLE - Pharm

Kaplan Section 2 Chapter 1 Autonomic Nervous System

QuestionAnswer
Formula for BP BP = CO x TPR (Bop's Co is a good Tipper)
Formula for CO CO = HR x SV (Give Co Her Sieve)
How would you block baroreceptor reflexes? Block at ganglionic synapse with Nn antagonists
How would you block a reflex bradycardia? the reflex is exerted by increase in PANS, so you would block with M (muscarinic) antagonists
How would you block a reflex tachycardia? the reflex is exerted by an increase in SANS, so block SANS with B1 antagonists
If you increase TPR by stimulating a1 receptors, what happens? You get reflex bradycardia from increase in PANS (M2 receptors)
If you decrease TPR by stimulating B2 receptors, what happens? You get reflex tachycardia from increase in SANS (B1 receptors)
What receptors are used in PANS? Nn at the ganglia and M on the organs
What does stimulating PANS do to the eyes? What receptor? M3. Contracts circular muscles --> miosis. Contracts ciliary muscles --> accomodation.
What does stimulating SANS do to the eyes? What receptors? a1 contracts the radial muscle, B relaxes the ciliary muscle --> mydriasis
What does stimulating SANS do for the heart? What receptors? B1 > B2. Accelerates SA node and pacemakers, increases contractility.
What does stimulating PANS do for the heart? What receptors? Decelerates SA node and decreases atrial contractility. M2
What does stimulating SANS do for the blood vessels? Which receptors? a contracts the vessels in the skin; B2 relaxes skeletal muscle vessels --> more blood to muscles for fight or flight
What does stimulating PANS do for the blood vessels? Which receptors? M3 - not innervated; only respond to circulating M3 agonists. Makes the endothelium release EDRF (endothelium derived relaxing factor) --> marked vasodilation.
What does stimulating SANS do to the bronchi? Which receptors? B2 - relax the smooth muscle in bronchi --> bronchorelaxation
What does stimulating PANS do to the bronchi? Which receptors? M3 - bronchoconstriction
What does stimulating SANS do to the GI/GU tract? Which receptors? a1 - contract sphincters; B2 - relax smooth muscle of organs; don't pee or poop!
What does stimulating PANS do to the GI/GU tract? Which receptors? M3 - relax sphincters and contract smooth muscle of GI tract and bladder; DO pee and poop!!
What does stimulating SANS do to the skin and sweat glands? Which receptors? a contracts the pilomotor smooth muscle (to make your hairs stand up) and increases secretion of apocrine (stress) sweat glands; M increases thermoregulatory sweat gland secretion
What does stimulating PANS do to the skin and sweat glands? Which receptors? nothing
What does stimulating SANS do to one's metabolism? Which receptors? a and B. a1 B2 Increase glucose (gluconeogenesis and glycogenolysis), increase lipolysis, B1 increase release of renin (converts angiotensinogen into ANG 1 --> vasoconstriction --> increase BP)
What governs erection and ejaculation? stimulate M in PANS for erection; stimulate a in SANS for ejaculation
What does the renin-angiotensin system respond to? Decreases in mean blood pressure, which leads to decreased renal blood flow
Created by: christinapham
 

 



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