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# Step 1 1.10.12

### Key Equations and Relations

Question | Answer |
---|---|

How do you calculate sensitivity? | =TP/(TP+FN) |

How do you calculate specificity? | =TN(TN+FP) |

How do you calculate positive predictive value? | =TP/(TP+FP) |

How do you calculate negative predictive value? | =TN(TN+FN) |

How do you calculate Relative risk? | = [a/a+b]/[c/c+d] |

How do you calculate attributable risk? | =[a/a+b]-[c/c+d] |

How do you calculate number needed to treat? | 1/absolute risk reduction |

How do you calculate number needed to harm? | 1/attributable risk |

How do you calculate Hardy Weinberg equilibrium? | p^2 + 2pq+q^2= 1 p+q=1 |

How do you calculate the henderson Hasselbach equation for CO3 and CO2? | pH=pKa+log[[HCO3-]/0.03 PCO2]] |

How do you calculate volume of distribution? | = amount of drug in body/plasma drug concentration |

How do you calculate ? | =rate of elimination of drug/plasma drug concentration |

How do you calculate Half life? | =0.7 x Vd/ CL (where Vd is volume of distorbution) |

How do you calculate loading dose? | LD=Cpx Vd/F |

How do you calculate maintenance dose? | MD= Cp x CL/F |

How do you calculate Cardiac output? | =rate of O2 consumption/ (arterial O2 content- venous O2 content) |

How do you calculate cardiac output via SV? | CO=SV x HR |

How do you calculate mean arterial P? | MAP=CO x total peripheral resistance. MAP= 1/3 systolic +2/3 distolic |

How do you calculate dstroke volume? | SV= End diastolic volume - end systolic volume |

How do you calculate ejection fraction? | EF=stroke volume/end diastolic volume x 100 |

How do you calculate resistance? | =driving pressure/ flow= 8 (nu=viscosity) x length/pi r^4 |

How do you calculate Net filtration pressure? | = [(Pc-Pi) - (pic-pii)] |

How do you calculate glomerular filtration rate? | GFR=U inulin cx V/P inulion= C inulin |

How do you calculate glomerular filtration rate via osmotic forces? | GFR= Kf[(Pgc-Pbs) - (piGC- piBS)] |

How do you calculate effective renal plasma flow? | ERPF= Upah x (V/Ppah) = Cpah |

How do you calculate renal blood flow? | RBF= RPF/(1-Hct) |

how do you calculate the filtration fraction? | FF=GFR/RPF |

How do you calculate physiological dead space? | Vd=Vt x [(PaCO2-PeCO2)/(PaCO2)] |