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DB- Introduction

Drugs and the Brain- Introduction Part A and Part B

QuestionAnswer
Describe the following drug: Nicotine -found in tobacco -may lower the risk of Parkinson's disease -binds to the Nicotonic Acetylcholine Receptor
Describe the following drug: Procaine a synthetic local anesthetic
Describe the following drug: Morphine a highly addictive pain killer
Describe the following drug: Botulinum toxin - one of the first protein drugs -variety of uses on the nervous system -many advantages
Rostral front
dorsal top
ventral bottom
caudal back
Synapse the point of information processing
Path of neuron signal presynaptic neuron--> synapse --> postsynaptic neuron
Neurons in the adult brain Development Period 10^11 First two years of life
Where does nicotine bind to its receptor? The acetylcholine binding protein interfacial= aromatic box
Three types of drug interactions? 1. Activate or block ion channels 2. Act on G Protein pathways 3. Act on transporters (neurotransmitter transporters)
Three Components of addiction? 1. Tolerance 2. Dependence 3. Goal Seeking Behavior
Metabolic Tolerance -occurs as metabolism of drugs becomes more efficient -primarily in the liver
Cellular Tolerance -occurs as neurons and neuronal circuits become less responsive
Contemporary vs Inside Out psychiatric drug treatment Contemporary treatment seeks to block classic binding sites at the synapse. Inside out blocks the same site, except with the cell at the ER and cis-Golgi.
Eroom's Law Drugs are becoming more expensive to R and D
Created by: cmwilson5
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