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Step 1 11.18.12

Pharm II

QuestionAnswer
What are the transmitters and receptors in the PSNS? ACH, nicotinic presyn, ACH muscarinic post syn
What sstems are under PSNS control? cardiac and AMM, gland cells, nerve terminals
What are the transmitters and receptors in sympathetic innervation of sweat glands? ACH, nicotinic, then ACH muscarinic
What are the transmitters and receptors in sympathetic innervation of sympathetic innervation of cardiac and SMM, gland cells, nerve terminals? ACH nicotinic, the Norepi, alpha and beta receptors
What are the transmitters and receptors in sympathetic innervation of renal vascular SMM? ACH nicotinic, dopamine, D1 receptor
What is the transmitter and receptor in the somatic innervation of SM? ACH, nicotinic receptors
What is unique about the innervation of the adrenal medulla and sweat glands? part of SNS, but innervated by cholinergic fibers
What is the action of botulinum toxin ? prevents release of NT ar all cholinergic terminals
What type of channel are Nicotinic ACH receptors and what are the 2 subtypes and where are they found? ligand gated Na/K+ channels, Nn found in autonomic ganglia, Nm found in NMJ
What is the type of channel in muscarinic ACH and what are the subtypes? G protein coupled receptors that act thru second messengers. 5 subtypes: M1-M5
What is the g protein class and major functions of the alpha 1 receptor? class: q fxn: incr vascular SMM contraction, incr pupillary dilator muscle contraction (mydriasis), incr intestinal and bladder sphincter contraction
What is the g protein class and major functions of the alpha 2 receptor? g prot: i. fx: decr sympathetic outflow, decr insulin release
What is the g protein class and major functions of the Beta 1 receptor? class: s fx: incr HR, incr contractility, incr renin release, incr lipolysis
What is the g protein class and major functions of the Beta 2 receptor? class: s fx: vasodilation, bronchodilation, incr HR, incr contractility, incr lipolysis, incr insulin release, decr uterine tone
What system are alpha 1, alpha 2, beta 1 , beta 2 a part of ? SNS
What is the g protein class and major functions of the M1 receptor? class: q fx: CNS, enteric NS
What is the g protein class and major functions of the M2 receptor? class:i fx: decr HR and contractility of atria
What is the g protein class and major functions of the M3 receptor? class: q fx: incr expocrine secretions )sweat gastric acid), incr peristalisis, incr bladder contraction, bronchoconstriction, incr pupillary sphincter muscle contraction (miosis) , ciliary m. contraction ( accomidation)
What system are the M1-M3 receptors part of? PSNS
What is the g protein class and major functions of the D1 receptor? class:s fx:relaxes renal vascular SMM
What is the g protein class and major functions of the D2 receptor? class: i fx: modulates transmitter release especially in the brain
What is the g protein class and major functions of the H1 receptor? class: q fx: incr nasal and bronchial muscus secretion, contraction of bronchioles, puritis and pain (histamine receptor)
What is the g protein class and major functions of the H2 receptor? class: s fx:incr gastric acid secretion
What is the g protein class and major functions of the V 1 receptor? vasopressin. class: q fx: incr vascular SMM contraction
What is the g protein class and major functions of the V2 receptor? vasopressin class: q fx: incr H20 permeability and reabsorbtion in collecting tubules of kidney
What is the mech of H1, alpha 1, V1, M1, M3 receptors? HAVE 1 M and M? Gq--->phopsholipase C--> lipids converted to PIP2---> activates IP3 and DAg/ DAG activates protein kinase C, IP3 causes calcium influx
What is the mech of Beta 1,2, D1,H2,D1? Gs, activates adenyl cyclase incr cAMP activating protein kinase A which incr Ca++ in heart, inhibits MLCK in SM
What is the mech of M2,alpha 2, D2? Gi. inhibits adenyl cyclase = decr cAMP...
Created by: tjs2123