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biotech exam 3
exam 3
| Question | Answer |
|---|---|
| how many transplants (exclude kidney) have been available to patients on the donor list for the last 10 years? | 2000-3000 |
| how many patients were on the transplant list in the us during the month of october 2011 | 100000-200000 |
| transplantation of a kidney between identical twins is an example of a | isograft |
| the required refferral system for organ donation | states that the local organ procurement organization determines whether an organ/tissue is appropriate for donation in each case |
| list the four categories of rejection reactions that are possible post-transplantation | hyperacute acute chronic graft vs. host |
| As demonstrated in the classic rejection experiment, the transfer of splenic T cells from a previously grafted mouse (graft from strain A mouse into strain B mouse) to a strain B mouse | will induce an accelerated rejection response against transplantation of a graft from a strain A mouse |
| which rejection of a transplant is based primarily upon antibody recognition (of donated tissue) by the recipient | hyperacute rejection |
| acute rejection reactions differ from chronic rejection reactions in that | antigen presenting cells are not required for direct killing of transplanted cells |
| passenger lymphocytes transferred during a bone marrow transplant can induce a rejection called | graft vs. host |
| immunosuppressant drugs are primarily used to suppress_____rejection reactions | chronic |
| transplanted xenogeneic tissue..... | includes the transfer of either cells, tissues or organs from one species to another |
| The two are the most common species for xenograft | 1. cow 2. pig |
| the most critical step for survival of transplanted tissue in a face transplant is... | attachment of underlying vasculature |
| The number/ratio of adults currently living with one or more types of CV disease is | 1 in 3 |
| Atherosclerosis... | includes the formation of both atheromas and calcified plaques |
| The main difference between soft and hard atherosclerotic plaques is | calcium is a significant component of hard but not soft plaques |
| what percentage of PCI is performed using stents | 70% |
| 5. Restenosis of coronary arteries is both a mechanical and biological process. Please name the mechanical process and the biological process involved. | mechanical: elastic recoil biologic: neointimal hyperplasia |
| OPCAB (off - pump coronary artery bypass)... | is a suitable procedure for bypassing up to 4 arteries |
| traditional CABG is preffered over MIDCAB because | more coronary artery vessels can be repaired at one time with the CABG procedure |
| surgeons performing the MIDCAB procedure can bypass | 1-2 vessels |
| replacement vessels used during coronary bypass procedures include all of the following except ... | allogeneic saphenous vein |
| cardiac valve failure that results in backflow of blood is called | regurgitation |
| the cardiac valve that is most often surgically replaced | the aortic semilunar valve |
| the type of replacement valve most often associated with calcification post-surgery is the | porcine tissue aortic valve replacement |
| choose the statement that is false | tissue valves are usually used for patients older than 65??? not sure about this one |
| Mechanical heart values .. | require patients to take anti-coagulants |
| trans-apical implantation of a prosthetic aortic valve is usually recommended for stunted tissue valves. true or false | true |
| cadaveric cardiac valve implantation... | requires no immunosuppression |
| an LVAD differs from a TAH in that | an LVAD can be used as a bridge to repair |
| a second generation LVAD differs from a first in its | mechanism for maintaining blood flow |
| implant-related infections that appear months post-operatively are usually associated with surgical contamination are called | deep late infections |
| The most frequent complication that patients experience following implantation of their VADs is... | neurological complications |
| The kidneys excrete approximately______L of water/day | 1.8 |
| Insulin is often used to measure ______in order to assess kidney function | glomerular filtration rate |
| Patients first become symptomatic of kidney failure when their clearence levels fall below _____% | 10% |
| Please NAME the two options available for vascular acess when preparing for hemodialysis | AV fistula artificial vascular graft |
| excess water is removed during dialysis as a result of | ultrafiltration |
| patient blood pressure, immediately following dialysis session, decreases prmarily because of... | the removal of water |
| The pathology underlying most hip and knee replacements is | cartilage degeneration |
| A patient is diagnosed with a damaged anterior cruciate ligament. The most likely course of treatment is.... | arthroscopy |
| The projected assesment of primary and revision TJR procedures in the US by the year 2030 states that | revisions and primary procedures will increase as compared to 2011 |
| an 18-year-old suffering with Rheumatoid Arthritis and progressive articular degeneration has been advised to have a hip replacement. This patient will most likely receive... | A CoCr implant with a porous trabecular coating |
| A mechanism of early failure of an artificial hip replacement is | dislocation |
| one drawback of the HMWPE (polymer) acetabular shell is... | generation of wear debris over time |
| The largest joint in the body is the____ | Knee |
| The largest weight bearing joint in the body is the_____ | hip |
| All of the following are true in regards to surface-mounted prosthetics except... | fibrous tissue formation at prosthetic/limb interface |
| Osseointegrated prosthetics... | are common devices used in dental replacement surgery |
| all of the following are true in regards to the iLimb except | has been modified to function on osseointegrated prosthetic |
| All of the following are true in regards to myoelectric devices except | they are operated by switches located on the residual stump |
| What percentage of amputees in the US have upper limb amputations | 10% |
| In the US, the primary cause for amputation is | complications from Diabetes |
| prevention of disease by administration of material from healing pustules either by inhalation or via small cuts in the skin is called | variolation |
| antibody responses induced by vaccination against specific pathogens are generated by | T helper cells and B cells |
| The FluMist Influenza vaccine is a | live attenuated vaccine |
| immunity of an individual to a specific disease that is based upon the vaccination of ana resulant protection by a group of closely associated individuals is called | herd immunity |
| the sabin polio vaccine had potential to actively infect patients that received it due to the fact that it was a live attenuated virus (t or f) | ture |
| administration of a purified component(s) of a pathogen that is (are) known to be immunogenic is an example of | subunit vaccine |
| vaccines that can be used to treat a chronic, pre-existing disease are called | theraputic vaccine |