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Cytokines
Pro-Inflammatory Cytokines
Question | Answer |
---|---|
Interleukin-1 (IL-1) actions? | Induces fever, stimulates production of prostaglandins, increases growth of CD4+ T cells |
Interleukin-2 (IL-2) actions? | Increases growth and differentiation of T-lymphocytes, enhances NK cell activity against cancer cells |
Interleukin-6 actions? | Stimulates liver to produce fibrinogen and protein C, increases rate of bone marrow production of stem cells, increases numbers of sensitized B-lymphocytes |
Tumor necrosis factor (TNF) | Induces fever, major cytokine involved in rheumatoid arthritis damage, increases leukocyte adhesion, participates in graft rejection, induces cachexia and muscle breakdown, incuces cell death, stimulates delayed hypersensitivity reactions and allergy |