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Pharm 4

chap 22

DrugClassIndicationMOACommon side effectsNotes
SSRI antidepressant depression,anxiety disorders (panic disorder, obasessive compulsive disorder block reuptake of serotonin and less effect on reuptake of norepinephrine nervousness, dizziness,insomnia,male sexual dysfunction (priapism and impotence); fewer autonomic effect and less sedation than Tricyclic better side effect profile;used in the morning b/c tend to increase alertness;used in caution with seizure,hepatic,diabetes,bipolar
MAOI antidepressant not a choice of depression treatment, only used when pt fails to respond to other drugs bind irreversibly to an enzyme monoamine oxidase (MAO) hypertensive crisis (occipital headache,palpitation,neck stiffness,soreness,nausea and vomitting,sweating,photophobia
lithium mood-stabilizing drug mood stabilizer: treat or prevent the manic phase of bipolar disorder reduce formation of IP3 drowsiness,weight gain,fine hand tremor,polyuria,hypothyroidism low therapeutic index' overdose: neurotoxicity,cardiac toxicity,arrhythmia,nausea,vomiting;nonsteroidal anti-inflammatory and diuretics decrease lithium clearance, increase level
Atomoxetine CNS stimulant ADHD cardiovascular incidents (high blood pressure, MI,sudden death),decrease in growth and weight gain in children unique norephinephrine reuptake inhibitor for ADHD
Modafinil CNS stimulant ADHD in children not approved for ADHD, "off-label" drug for ADHD
Amitriptyline tricyclic's, tertiary amines depression block serotonin reuptake to a greater exten than do secondary amines more sedation adn autonomic side effects than secondary amines
Nortriptyline Tricyclic, secondary amines depression block norepinephrine reuptake than serotonin reuptake autonomic side effects and sedation (less than amitriptyline)
Olanzapine atypical antipschotic agents positive and negative sypmtoms of schizophrenia chemical analog of clozapine sedation,weight gain produce few EPS effects than haloperidol, fewer autonomic side effects
Amphetamines CNS stimulant ADHD, sleep apnea, shift-work sleep, obesity Schedule II, CV incidents, Decreased growth & weight gain
Typical antipsychotics (1st generation) antipsychotic drugs Psychoses, Schizophrenia, Tourette’s, Agitation PRN have equal or greater affinity for D2 receptors than for 5 HT2 receptors, block dopamin and serotonin Extrapyramidal symptoms(EPS)(akathisia, pseudoparkinsonism,dystonias), Tardive dyskinesia
Atypical antipsychotic drugs (2nd gen) antipsychotic drugs have greater affinity for 5-HT receptors than for D2 receptors, block dopamin and serotonin fewer EPS symptoms than typical
All antidepressant medications Box warning risk of incresased suicidal thoughts and behavior in children and adolescents and adults
Tricyclic antidepressant depression block neuronal reuptake of norepinephrine and serotonin autonomic side effects(hypotension,sinus tachycardia,excessive sedation,seizures), cardiac arrhythmia) used at night b/c of its sedation
Created by: prinluu