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Pharm 4

Chap 20

QuestionAnswer
Drug for status epilepticus Diazepam, lorazepam, phenobarbital, fosphenytoin
Drug interaction Carbamazepine and phenytoin induce cytochrome P450 enzymes and decrease serum levels of the drugs with which they interact
Drug interaction Valproate inhibits the metabolism of the drugs with which it interacts
Epilepsy and pregnancy Valproate and phenytoin cause birth defects and both can reduce folate levels
Carbamazepine seizures, trigeminal neuralgia (pain on one or both side of face), bipolar disease
Epilepsy and pregnancy Valproate and phenytoin cause birth defects and both can reduce folate levels
Carbamazepine seizures, trigeminal neuralgia (pain on one or both side of face), bipolar disease
Carbamazepine cause drowsiness, ataxia, CNS depression, GI
Phenytoin contraindication not use in children and pregnancy
Phenytoin cause: megaloblratic anemia, birth defects, fetal hydantoin syndrome (cardiac defects, malformation of ears, lips, palate, mouth and nasal bridge, mental retardation, microcephaly; ataxia, diplopia, nystagmus, slurred speech;
Phenytoin cause osteomalacia; gingival hyperpalsia, excessive hair growth (hirsutism)
Topiramate use adjunct use for partial seizures
Topiramate reduce serum level of oral contraceptives
Topiramate s/e ataxia, dizziness, drowsiness
Topiramate have several mechanisms of actions, halflife 21 hours, metabolism induced by carbamazepine and phenytonin
Ethosuximide first choice in treatment of absence seizure in children, not for adults (valproate instead)
Ethosuximide valproate inhibits metabolism and increase serum levels, effect is altered by Haloperidol
gabapentin GABA analogue, increase the release of GABA from central neurons, absorption from the gut is inversely related to the dose
gabapentin treat all forms of partial seizures
gabapentin s/e ataxia, dizziness, drowsiness, nystagmus, tremor
Benzo used in seizure treatment clonazepam, diazepam (IV), lorazepam (IV)
Benefits of benzo produces more sedation than other antiepileptic drugs
Created by: prinluu