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Histamine Receptor

Pharmacology

QuestionAnswer
HISTAMINE RECEPTOR REVIEW H1 receptors: brain, skin, bronchi, and blood vessels. H stands for histamine.
ACTION OF HISTAMINE Keep us alert; influences development of urticaria, angioedema, bronchoconstriction and widespread vasodilation.
ANTIHISTAMINE/H-1 ANTAGONIST Reverse urticaria and angioedema but don't relax bronchoconstriction or reverse vasodilation.
Dimetapp Brompheniramine; sedating H1 blocker
Cetirizine Zyrtec; sedating H1 blocker
Chlorpheniramine Chlortrimeton; sedating H1 blocker
Clemastine Tavist; sedating H1 blocker
Cyproheptadine Periactin; sedating H1 blocker
Dimenhydrinate Dramamine; sedating H1 blocker; DOC motion sickness
Diphenhydramine Benadryl; sedating H1 blocker; DOC urticaria and hypersensitivity reactions; when someone has an allergy to a drug that MUST be given benadryl may be prescribed w/ corticosteroid.
Hydroxyzine Atarax; sedating H1 blocker; DOC severe itching uncontrolled other methods
Uses of H-1, sedating blockers Allergic rhinitis; urticaria; hypersensitivity reactions; itching; motion sickness; antitussives; allergy prevention; parkinson's; drug-induced parkinsonism;
PARKINSONS AND ANTIHISTAMINES Dopamine and acetylcholine are inversely related. Antihistamines have anti-cholinergic effects. If acetylcholine decreases/dopamine increases. Want a drug like benadryl crosses the BBB so we might want to use if for Parkinsons.
PERIACTIN Appetite stimulant adults and prevents cluster headaches-but NOT APPROVED FOR THESE. Effective severe itching uncontrolled other methods or other typical antihis uses.
DOC DYSTONIA 50 OR 100 MG IM IN ADULT PATIENT-effects will almost be immediate
COGENTIN DOC DRUG INDUCED PARKINSONISM
PRECAUTIONS ANTIHISTAMINES Don't drive car, bike; machinery; plane -none before 24 to 48 hrs before; causes lack of coordination.
SIDE EFFECTS Drowsiness; hyperactivity in elderly or young
Created by: jniebyls
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