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Staphylococcuss
diseases and virulence factors
| Question | Answer |
|---|---|
| All pathogenic staph. have this biochemical characteristic | catalase positive |
| antiphagocytic virulence factors | carbohydrate capsules techoic acid |
| toxins that cause hemolysis of RBC's | alpha, beta, delta, epsilon |
| toxins that have leukocidal activity | alpha and delta |
| species that sometimes produce exfoliative toxin | S. aureus aureus S. hyicus hyicus |
| Bacteriophage typing | -staph. differ in susceptibility to lytic bacteriophages -use this to differentiate species/substecies, esp. with S. aureus aureus |
| diseases associated with S. hyicus hyicus | porcine exudative epidermitis |
| diseases associated with S. aureus aureus | -strains that make exfoliative toxin => human skin infection -bovine mastitis -canine pyoderma (10%) -human staphylococcal foodborne infection |
| Human Staphylococcal foodborne infection etiology (enterotoxin info) | -enterotoxin-producing strains -plasmid-mediated toxins (A-K minus I and J) ==identical modes of action ==heat-stable at 100C for 30 min -only some strains have plasmids -usually only produce 1 enterotoxin |
| Human Staphylococcal foodborne infection transmission | ingestion |
| Human Staphylococcal foodborne infection clinical features | -contaminated food held at inappropriate temperatures long enough for strains to proliferate and make enterotoxin -incubation: 4 hours -symptoms: 12-24 hours |
| Human Staphylococcal foodborne infection pathogenesis | -enterotoxins are chem/immunologically related -related enterotoxins act as superantigens |
| Human Staphylococcal foodborne infection pathology | watery diarrhea with no blood |
| Human Staphylococcal foodborne infection DX | culture from contaminated food, text for enterotoxin using commercial kit |
| diseases associated with Staphylococcus psuedintermedius | Canine pyoderma (90%) |
| Canine Pyoderma etiology | grape-like clusters |
| Canine Pyoderma transmission | -endogenous skin flora -sometimes from direct contact with clinically infected -rarely form asymptomatic carriers |
| Canine Pyoderma clinical features | -intact skin tends to be resistant -factors that negatively affect skin integrity predispose -suppurative exudate |
| Canine Pyoderma pathogenesis (virulence factors) | -carbohydrate capsule -cell wall antigens -extracellular enzymes -exotoxins |
| Canine Pyoderma pathology | -skin with suppurative exudate -sometimes lymphadenitis, esp. superficial ln's |
| Canine Pyoderma DX | -G+, nonmotile, cocci, grapelike clusters -S. aureus auresu => double zone hemolysis -S. pseudintermedius complete hemolysis -catalase + -saccharolytic -coagulase rabbit plasma |
Created by:
jesters
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