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Durgs and durgs

QuestionAnswer
Phenobarbital EPILEPSY Luminal Tonic-Clonic, Partial Potentiates GABA
Phenytoin EPILEPSY Dilantin, Diphenylan Tonic-Clonic, Partial Slows Na channels Warfarin Metabolism Slowed SJS
Carbamazepine EPILEPSY Tegretol, Carbatrol Tonic-Clonic, Partial, Bipolar, PRIMARY* Slows Na Channels
Oxcarbazepine EPILEPSY Trileptal Partial Seizures in 4-16 Slows Na Channels
Ethosuximide EPILEPSY Zarontin Absence PRIMARY* T-Type Ca
Valproic Acid EPILEPSY Depakote, Depakene Absence, Myclonic, Partial, Tonic-Clonic T-Type Ca, Slow Na, Increase GABA Broad Spectrum Migraine too
Gabapentin EPILEPSY Neurontin Adjunctive for partial Neuropathic Pain Unknown Mechanism Excreted In Urine Migraine too
Lamotrigine EPILEPSY Lamictal Partial and Tonic-Clonic Slows Na Channels
Topiramate EPILEPSY Topomax Partial, Tonic-Clonic Slow Na Channels, AMPA-Kainate, GABA Migraine too
Levetiracetam EPILEPSY Keppra Adjunctive for partial, Tonic-Clonic in ADULTS Myoclonic in CHILDREN IV for Status Epilepticus High Safety Margin, Good for Adjunctive
Diazepam, Larazepam* EPILEPSY IV Status Epilepticus 5-10mg then 20-30mg
Ergotamine Tartrate MIGRAINE Oral, Sublingual, Suppository Limit 6mg or 10mg per week. "Dirty" Agonist at alpha and 5HT1b and 5HT2 Reduces Neurologic Inflamation
Metoclopramide Reglan Treats GI upset in Ergotamine treatment
Dihydroergotamine MIGRAINES Parenterally 5HT1 Vasospasm Less likely then Ergotamine
Sumatriptan MIGRAINES Imitrex SC or oral Causes Constriction, inhibits vasodialator Relieves nausea, photophobia Not for Heart Disease, reports of death SC Contraindicated with MAO-Is (Phenelzine, Isocarboxazid)
Zolmitriptan, Rizatriptan MIGRAINES Triptan like Imitrex More lipophilic, better absorbed Affect Trigeminal Nucleus
Prochlorperazine MIGRAINES Compazine Dopamine Antagonist IV or IM Used when nothing else works relieves pain and is anti-emetic
Methysergide MIGRAINES Sansert Prevents Migraines, last resort Metabolized to methylergometrine 5HT2 antagonist, 5HT1 agonist Protection takes 1-2 days to develop Fibrosis* 4 week breaks every 6months LSD like effects
Beta Blockers MIGRAINES Not Pindolol or Acetbutanol,
Amitriptyline MIGRAINES Elavil Antidepressant Downregulates Central 5HT2 and Adrenergic
Morphine OPIOID Sulfate Salt Not effective Orally 10mg IM of SC
Codeine OPIOID Oral Mild pain, Antitussant
Hydromorphone OPIOID Dilaudid, Palladone More Potent Morphine
Oxycodone OPIOID Roxicodone, Percodan, Oxycontin Orally alone or with acetaminophen Oxycontin is sustained release for chronic
Hydrocodone OPIOID Lartab, Lorcet, Vicodin, Norco Usually with acetaminophen Most widely prescribed
Meperidine OPIOID Demerol Short acting Build up of metabolite, normeperidine causes seizures Less constipation and respiratory depression from smooth muscle contraction
Heroin OPIOID Diacetylmorphine More Potent and Euphoric Not used in US. Injected, smoked, snorted
Methadone OPIOID Dolophine Less Euphoric, Longer Action chronically Analgesic and treats Addiction
Propoxyphene OPIOID Darvon Less potent Severe Risk for Cardiac Toxicity Withdrawn in 2010
Fentanyl OPIOID 100x More Potent Supplement Surgical Anesthesia Duragesic, Patch for Chronic Pain Actiq, Lozenge Innovar, added to droperidol for neuroleptic analgesia
Opioid Combinations Codeine/Acet Codeine/Aspririn Hydro/Acet Hydro/Ibu Oxy/Acet
Pentazocine OPIOID AGONIST-ANTAGONIST Talwin, Talwin NX Kappa agonist, mu antagonist high doses NX has naloxone to reduce IV abuse
Butorphanol OPIOID AGONIST-ANTAGONIST same
Buprenorphine OPIOID AGONIST-ANTAGONIST Buprenex. Subutrex, Suboxone Sublingual, injection, intranasally Less abuse Mu agonist, kappa antagonist Treats heroin addicts Suboxone has Naloxone to prevent injection
Tramadol OPIOID AGONIST-ANTAGONIST Ultram Supposed to be less abused Inhibits reuptake of norepinephrine and serotonin
Naloxone OPIOID ANTAGONIST Narcan Not effective orally Treats the Overdose Short
Naltrexone OPIOID ANTAGONIST ReVia Long acting, immunizes addicts treats alcoholics Patients should be brought through withdrawal before therapy
Methylnaltrexone OPIOID ANTAGONIST Relistor Treats opioid induced constipation SC must be serious constipation
Alvimopan OPIOID ANTAGONIST Entereg Same as Methylnaltrexone but ORAL
Indomethacin GOUT Indocin NSAID Can Cause CNS side effects
Ibuprofen GOUT Motrin NSAID
Ketoralaz GOUT Toradol Injectable NSAID analgesic
Colchicine GOUT Colcrys Binds to tubulin, reduces leukocyte migration Sever Diarrhea, GI upset Effective but expensive, limited availability, bad side effects
Allopurinol GOUT Xyloprim Inhibits xanthine oxidase Reduces uric acid synthesis Preventative, Causes acute attacks at start
Febuxostat GOUT Uloric Better allopurinol but more expensive Less allergic reactions
Probenecid GOUT Benemid Increases uric acid excretion by inhibiting organic acid movement Increase risk of kidney stones
Created by: amarche1
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