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PHAR134 exam 2 Drugs

Drug Classes

QuestionAnswer
Carbachol nonselective cholinergic agonist (carbamate bioisostere, less prone to HOH)
Acetylcholine nonselective cholinergic agonist
Methacholine selective muscarinic agonist (less prone to HOH)
Pilocarpine selective muscarinic agonist (tertiary amine)
Bethanechol selective muscarinic agonist (long acting)
Muscarine selective muscarinic agonist
Edrophonium competitive, reversible AChE inhibitor
Donepezil competitive, reversible AChE inhibitor (tertiary)
Pyridostigmine noncompetitive, reversible AChE inhibitor (slow onset, long duration)
Neostigmine noncompetitive, reversible AChE inhibitor (rapid onset, intermediate duration)
Physostigmine noncompetitive, reversible AChE inhibitor (tertiary)
Demercarium noncompetitive, reversible AChE inhibitor
Ambenonium noncompetitive, reversible AChE inhibitor
Echothiophate irreversible AChE inhibitor
Parathion irreversible AChE inhibitor
Malathion irreversible AChE inhibitor
Sarin irreversible AChE inhibitor
Soman irreversible AChE inhibitor
Tabun irreversible AChE inhibitor
Pralidoxime organophosphate poisoning antidote
Homatropine direct acting anticholinergic (topical admin=local effect)
Tropicamide direct acting anticholinergic (topical admin=local effect)
Cyclopentolate direct acting anticholinergic (topical admin=local effect)
Atropine direct acting anticholinergic
Scopolamine direct acting anticholinergic
Ipratropium direct acting anticholinergic (quaternary)
Tiotropium direct acting anticholinergic (quaternary)
Dicyclomine direct acting anticholinergic
Oxybutynin direct acting anticholinergic
Tolterodine direct acting anticholinergic (selectivity for bladder tissue)
Trospium direct acting anticholinergic (quaternary)
Solifenacin direct acting anticholinergic (selective M3>M1)
Darifenacin direct acting anticholinergic (selective M3>M1)
Glycopyrrolate direct acting anticholinergic (quaternary)
Hemicholinium indirect acting anticholinergic - block active transport of choline into nerve terminal
Vesamicol indirect acting anticholinergic - block transport of ACh into vesicle
Botulinum toxin indirect acting cholinergic - prevent vesicle fusion & release of ACh
Nicotine nicotinic agonist
DMPP nicotinic agonist (selective for autonomic ganglionic cells)
Hexamethonium ganglionic blocker
Trimethaphan ganglionic blocker
Mecamylamine ganglionic blocker
Isoproterenol nonselective beta agonist
Dobutamine beta-1 selective agonist
Metaproterenol short acting beta-2 selective agonist
Terbutaline short acting beta-2 selective agonist
Albuterol short acting beta-2 selective agonist
Salmeterol long acting beta-2 selective agonist
Formoterol long acting beta-2 selective agonist
Phenylephrine alpha-1 selective agonist
Tetrahydrozoline alpha-1 selective agonist
Naphazoline alpha-1 selective agonist
Clonidine alpha-2 selective agonist
Amphetamine indirect adrenergic agonist - releasing agent
Methamphetamine indirect adrenergic agonist - releasing agent
Cocaine indirect adrenergic agonist - reuptake inhibitor
Selegiline indirect adrenergic agonist - MAO inhibitor
Ephedrine mixed action adrenergic agonist. direct alpha & beta, and indirect acting (erythro isomer)
Pseudoephedrine mixed action adrenergic agonist. predominately indirect acting(threo isomer)
Phentolamine nonselective alpha antagonist
Phenoxybenzamine nonselective alpha antagonist
Prazosin selective alpha-1 antagonist
Terazosin selective alpha-1 antagonist (+ apoptosis of prostate cells)
Doxazosin selective alpha-1 antagonist (+ apoptosis of prostate cells)
Alfuzosin selective alpha-1 antagonist
Tamsulosin selective alpha-1a antagonist
Silodosin selective alpha-1a antagonist
Yohimbine selective alpha-2 antagonist
Propranolol nonselective beta antagonist
Pindolol nonselective beta antagonist + ISA
Metoprolol selective beta-1 antagonist
Atenolol selective beta-1 antagonist
Labetolol nonselective beta antagonist + alpha-1 antagonist
Carvedilol nonselective beta antagonist + alpha-1 antagonist + anti-inflammatory
Reserpine indirect andrenergic antagonist - block vesicular monoamine transporter, depleting NE
Tyramine indirect adrenergic antagonist - "false transmitter" that displaces NE
Metyrosine indirect adrenergic antagonist - inhibit tyrosine hydroxylase (TH)
Created by: steponmegrace