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PHAR134 exam 2 Drugs
Drug Classes
| Question | Answer |
|---|---|
| Carbachol | nonselective cholinergic agonist (carbamate bioisostere, less prone to HOH) |
| Acetylcholine | nonselective cholinergic agonist |
| Methacholine | selective muscarinic agonist (less prone to HOH) |
| Pilocarpine | selective muscarinic agonist (tertiary amine) |
| Bethanechol | selective muscarinic agonist (long acting) |
| Muscarine | selective muscarinic agonist |
| Edrophonium | competitive, reversible AChE inhibitor |
| Donepezil | competitive, reversible AChE inhibitor (tertiary) |
| Pyridostigmine | noncompetitive, reversible AChE inhibitor (slow onset, long duration) |
| Neostigmine | noncompetitive, reversible AChE inhibitor (rapid onset, intermediate duration) |
| Physostigmine | noncompetitive, reversible AChE inhibitor (tertiary) |
| Demercarium | noncompetitive, reversible AChE inhibitor |
| Ambenonium | noncompetitive, reversible AChE inhibitor |
| Echothiophate | irreversible AChE inhibitor |
| Parathion | irreversible AChE inhibitor |
| Malathion | irreversible AChE inhibitor |
| Sarin | irreversible AChE inhibitor |
| Soman | irreversible AChE inhibitor |
| Tabun | irreversible AChE inhibitor |
| Pralidoxime | organophosphate poisoning antidote |
| Homatropine | direct acting anticholinergic (topical admin=local effect) |
| Tropicamide | direct acting anticholinergic (topical admin=local effect) |
| Cyclopentolate | direct acting anticholinergic (topical admin=local effect) |
| Atropine | direct acting anticholinergic |
| Scopolamine | direct acting anticholinergic |
| Ipratropium | direct acting anticholinergic (quaternary) |
| Tiotropium | direct acting anticholinergic (quaternary) |
| Dicyclomine | direct acting anticholinergic |
| Oxybutynin | direct acting anticholinergic |
| Tolterodine | direct acting anticholinergic (selectivity for bladder tissue) |
| Trospium | direct acting anticholinergic (quaternary) |
| Solifenacin | direct acting anticholinergic (selective M3>M1) |
| Darifenacin | direct acting anticholinergic (selective M3>M1) |
| Glycopyrrolate | direct acting anticholinergic (quaternary) |
| Hemicholinium | indirect acting anticholinergic - block active transport of choline into nerve terminal |
| Vesamicol | indirect acting anticholinergic - block transport of ACh into vesicle |
| Botulinum toxin | indirect acting cholinergic - prevent vesicle fusion & release of ACh |
| Nicotine | nicotinic agonist |
| DMPP | nicotinic agonist (selective for autonomic ganglionic cells) |
| Hexamethonium | ganglionic blocker |
| Trimethaphan | ganglionic blocker |
| Mecamylamine | ganglionic blocker |
| Isoproterenol | nonselective beta agonist |
| Dobutamine | beta-1 selective agonist |
| Metaproterenol | short acting beta-2 selective agonist |
| Terbutaline | short acting beta-2 selective agonist |
| Albuterol | short acting beta-2 selective agonist |
| Salmeterol | long acting beta-2 selective agonist |
| Formoterol | long acting beta-2 selective agonist |
| Phenylephrine | alpha-1 selective agonist |
| Tetrahydrozoline | alpha-1 selective agonist |
| Naphazoline | alpha-1 selective agonist |
| Clonidine | alpha-2 selective agonist |
| Amphetamine | indirect adrenergic agonist - releasing agent |
| Methamphetamine | indirect adrenergic agonist - releasing agent |
| Cocaine | indirect adrenergic agonist - reuptake inhibitor |
| Selegiline | indirect adrenergic agonist - MAO inhibitor |
| Ephedrine | mixed action adrenergic agonist. direct alpha & beta, and indirect acting (erythro isomer) |
| Pseudoephedrine | mixed action adrenergic agonist. predominately indirect acting(threo isomer) |
| Phentolamine | nonselective alpha antagonist |
| Phenoxybenzamine | nonselective alpha antagonist |
| Prazosin | selective alpha-1 antagonist |
| Terazosin | selective alpha-1 antagonist (+ apoptosis of prostate cells) |
| Doxazosin | selective alpha-1 antagonist (+ apoptosis of prostate cells) |
| Alfuzosin | selective alpha-1 antagonist |
| Tamsulosin | selective alpha-1a antagonist |
| Silodosin | selective alpha-1a antagonist |
| Yohimbine | selective alpha-2 antagonist |
| Propranolol | nonselective beta antagonist |
| Pindolol | nonselective beta antagonist + ISA |
| Metoprolol | selective beta-1 antagonist |
| Atenolol | selective beta-1 antagonist |
| Labetolol | nonselective beta antagonist + alpha-1 antagonist |
| Carvedilol | nonselective beta antagonist + alpha-1 antagonist + anti-inflammatory |
| Reserpine | indirect andrenergic antagonist - block vesicular monoamine transporter, depleting NE |
| Tyramine | indirect adrenergic antagonist - "false transmitter" that displaces NE |
| Metyrosine | indirect adrenergic antagonist - inhibit tyrosine hydroxylase (TH) |
Created by:
steponmegrace
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