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Pharm test 3
chap 30
| Question | Answer |
|---|---|
| Aspirin indications | pain, fever, inflammation |
| Aspirin indications | myocardial infarction, stroke, throboembolic disorder |
| aspirin contraindication | not used in children bc it causes Reye's syndrome |
| aspirin adverse effects | gastric irritation |
| aspirin adverse effects | GI bleeding and peptic ulcers |
| aspirin adverse effects | Tinitus (abnormal auditory sensation or buzzing noise) |
| salicylates adverse effects (aspirin) | fever |
| salicylates adverse effects (aspirin) | dehydration |
| salicylates adverse effects (aspirin) | severe metabolic acidosis |
| excessive doses of aspirin | hypoprothrombinemia (impairment of hemostasis and bleeding) |
| aspirin sensitivity occurs | in person with asthma, nasal polyps, chronic urticaria |
| Tylenol (acetaminophen) adverse effect | renal dysfunction |
| Tylenol (acetaminophen) adverse effect | hepatotoxicity |
| Tylenol (acetaminophen)indications | mild pain and fever |
| Ibuprofen, Naprofen indications | for fever, pain and inflammation caused by trauma, infection, autoimmune disorders, neoplasms, joint degeneration |
| NSAIDs moa | antipyretic effects (inhibit COX isozymes and synthesis of prostaglandins) |
| NSAIDs moa | analgesic effects (inhibit COX isozymes and synthesis of prostaglandins) |
| NSAIDs moa | anti-inflammatory effects (inhibit COX isozymes and synthesis of prostaglandins) |
| Ibuprofen, Naprofen adverse effects | gastric irritation |
| Ibuprofen, Naprofen adverse effects | nausea |
| Ibuprofen, Naprofen adverse effects | dyspepsia |
| Ibuprofen, Naprofen adverse effects | bleeding |
| Ibuprofen, Naprofen adverse effects | peptic ulcer disease |
| indomethacin (Indocin),ketolorac (Toradol) *oral out pt. dosing* | Pain, inflammation, (infant) patent ductus (Indocin) |
| indomethacin (Indocin),ketolorac (Toradol) adverse effects | GI and CNS side effect |
| methotrexate (Rheumatrex); leflunomide (Arava); hydroxychloroquine (Plaquenil) | GI, liver function, diarrhea, alopecia, ocular effects Category X |
| etanercept (Enbril) (immunomodulators)indication | RA |
| Prednisone (steroid) | treatment of RA |
| Glucocorticoids (steroid) | act more rapidly than other DMARDS |
| Gold salt adverse effect | hemetologic, dermatologic, GI, renal effects. |
| Gold salt adverse effect | flushing, hypotension, tachycardia |
| Gold salt adverse effect | skin rash, stomatitis |
| methotrexate (Rheumatrex) | Autoimmune disorders |
| leflunomide (Arava) | Autoimmune disorders |
| hydroxychloroquine (Plaquenil) | Autoimmune disorders |
| methotrexate (Rheumatrex); leflunomide (Arava); hydroxychloroquine (Plaquenil) | GI, liver function, diarrhea, alopecia, ocular effects Category X |
| allopurinol (Zyloprim) | GI, dizziness, sore gums, hepatitis |
| probenecid (Benemid) | GI, dizziness, sore gums, hepatitis |
| allopurinol (Zyloprim); probenecid (Benemid) | sore gums |
| allopurinol (Zyloprim); probenecid (Benemid) | hepatitis |
| allopurinol (Zyloprim); probenecid (Benemid) | prevent gout |
| allopurinol (Zyloprim) | prevent gout , overproduce uric acid > 800 |
| probenecid (Benemid) | prevent gout , underproduce uric acid < 800 |
| indomethacin (Indocin) other NSAIDS colchicine (Colcrys) | treat gout attack |
| colchicine (Colcrys) | treat gout attack |
| indomethacin (Indocin) other NSAIDS colchicine (Colcrys) adverse effects | GI |
| sulfasalazine | treatment of RA |
| Sulfasalazine contraindicated | not for those who are allergic to sulfa compounds |
| methotrexate, leflunomide contraindication | not for pregnant women |
| celecoxib indications | osteoarthritis and RA |
| celecoxib adverse effects | cardiovascular events, diarrhea, dyspepsia, abdominal pain |
| colchicine adverse effects | nausea, vomiting, diarrhea, abdominal cramps |
| indomethacin: | hematological toxicity |
| indomethacin monitored | short-term use, closely monitored |
| Ketorolac special route in NSAIDs | parenteral IV or IM |
| Ketorolac indications | moderate pain postoperative pain associate with dental surgery, migraine headaches, allergic conjunctivitis, ocular inflammation |
| Ketorolac cautions | cause increased risk in renal or hepatic disease |
| Pinoxicam | chronic treatment of RA |
| Advantage of Pinoxicam | 50 hour plasma half-life |
| Nabumetone | prodrug, advantage half-life of 20 hours: allow once daily dosing |
| Diclofenac | treat pain associated with osteoarthritis in joint (topical) |
| Long-term use of NSAIDS cause | renal or hepatic toxicity |
| Nonselective COX inhibitors except Tylenol | cause gastric irritation and bleeding, longterm cause peptic ulcers |
| Acetaminophen weakness | lacks significant anti-inflammatory and antiplatelet activity |
| Celecoxib | the first and only selective COX inhibitor, cause less GI bleeding and peptic ulcers than nonselective COX inhibitors |
| Treatment of RA | NSAIDS- relieve pain and inflammation; and DMARDs - suppress underlying disease and slow joint destruction |
| treatment of osteoporosis | NSAIDs |
Created by:
prinluu
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