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Micro lecture 10

QuestionAnswer
How many Da does a Light chain have in an antibody? 22,000
How many Da does a Heavy chain have in an antibody? 55,000
What are the 2 different kinds of Light chain parts? λ and K
A V-J combination is caused by a ___ _________ ____. DNA recombination event
What is a V region? a variable region
What is a J region? a joining region
Name the steps of light chain production DNA rearrangement (V-J joining), RNA transcription and splicing, protein translation and processing.
Name the 5 different kinds of Heavy chain antibody classes (isotypes). μ, γ, α, δ, or ε
Name the steps of heavy chain production DNA rearrangement (D-J joining), DNA rearrangement (V-DJ joining), RNA transcription and splicing, protein translation and processing.
DNA rearrangements causes enormous _________ __________ in the variable region of the light and heavy chains. sequence diversity
Antibody classes can switch in heavy chains, T/F? True
What do antibodies do? opsonization, antibody dependent cellular cytortoxicity (ADCC), neutralization, agglutination, mast cell degranulation, complement activation via the classical pathway.
How does IgM activate the complement pathway? It binds to the epitopes on pathogen cell surfaces to expose Fc sites for binding of C1.
What does IgM do? Where is it found? complement activation, neutralization, agglutination. Found on B cells.
What does IgG do? Where is it found? complement activation, opsonization, neutralization. Found in blood, transported to tissues.
What does IgA do? Where is it found? Protects against microbes at major ports of entry. Found in secretions.
What does IgE do? Where is it found? Defends against helminths (parasitic worms). Found in low concentration in blood, or bound to high affinity FcE receptors on mast cells and basophils.
What does IgD do? Where is it found? Antigen receptor (on naive B cells). Found in low concentration in blood.
Name some lymphoid organs. Thymus, bone marrow, lymph nodes, spleen, mesenteric lymph nodes, lamina propria, Peyer's patches
Two parts of B-cell maturation. Bone marrow, antigen independent; Periphery, antigen dependent.
Name the stages of B-cell maturation in the Bone marrow, antigen independent part. Lymphoid stem cell, Pro-B cell, Pre-B cell, Immature B cell
Name the stages of B-cell maturation in the Periphery, antigen dependent part. Naive B cell, Mature B cell
What happens between the Lymphoid stem cell stage and the Pre-B cell stage? DNA rearrangement to make a mu heavy chain, and the assembly of the surface receptor from the heavy chain and the surrogate light chain.
What happens to turn a Pre-B cell into an Immature B cell? DNA rearrangement to make a light chain, the assembly of the surface receptor, display of BCR, and elimination of cells that react with "self" antigens.
How does an Immature B cell turn into a Mature B cell? They express both IgM and IgD on their surface.
What are T cells? heterodimers of α/β or γ/δ chains
Class I and Class II MHC both show ____ ______. peptide antigens
MHC Class I is expressed on almost all ______ ____. nucleated cells
Class II MHC is expressed on ________ ______ _____. Antigen presenting cells (APCs), like macrophages, dendritic cells, and B cells.
Name 2 antigen presentation pathways. Endogenous pathway, exogenous pathway.
Name the steps of the endogenous pathway. Start with intra-cellular pathogens (i.e. viruses) or "altered self" antigens. MHC Class I presented on nucleated cells. CD8+ T-cell response.
Name the steps of the exogenous pathway. Extra-cellular pathogens (i.e. bacteria) or other antigens that have been phagocytosed. MHC Class II presents on APCs (macrophages, etc.). CD4+ T-cell response.
Through what are the plasma membrane proteins transported? The Golgi apparatus and secretory vesicles.
Created by: deleted user
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