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CellCycleRegulators
Cell Cycle Regulators
| Question | Answer |
|---|---|
| ________ limits the number of times a cell can divide | aging |
| growth control mechanisms allow ______ _______ only under certain conditions | cell division |
| Healing - cells will divide until the wound closes and new cells touch or come in contact with neighboring cells. Then _________ ________ will cause cell division to cease. | contact inhibition |
| a family of proteins whose concentrations fluctuate throughout the cell cycle | cyclins |
| each type of cyclin accumulates during a different phase and _________ ___ __________ of the cell into the next phase of the cell cycle. | stimulates the passage |
| Growth control also depends on several _________ ___________ _________ which also regulate passage of the cell through the cell cycle | tumor suppressor proteins |
| unregulated cell division: | cancer |
| Cancer cells divide uncontrollably forming masses of cells called __________ | tumors |
| Tumors grow at the expense of surrounding _________ ____ __________ | cells and tissues |
| Cancer cells may break free from tumors and circulate through the body causing ___________ of the cancer | metastasis |
| An astonishing number of cancer cells have a mutation in the _____ gene which halts the cell cycle until all chromosomes have properly replicated. | p53 |
| which type of muscle tissue can divide? | smooth muscle |
| Chromosomes are made up of DNA wound tightly around __________ proteins. | histone |
| DNA wound tightly around eight histone proteins forms a __________ unit. | nucleosome |
| Nucleosomes are often referred to as “__________” on a string with the “string” being the DNA | beads |
| Folding reduces the average chromosome from a length of about _____ to about _____ however, the average nucleus is only 5um | 5 cm, 1 mm |