Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Pharm test 3
chap 28
| Question | Answer |
|---|---|
| • Drugs for Peptic Ulcer Disease | H2 receptor antagonists ;Proton Pump Inhibitors ;Gastric Antacids ;Cytoprotective Drugs |
| • Drugs for Inflammatory Bowel Diseases | Mesalamine (Asacol) (Pentasa) (Rowasa) (Canasa) ;Sulfasalazine (Azulfidine) ;Budesonide (Entecort) ;Other steroids (hydrocortisone, et al) ;Biologics (infliximab and other -mabs) |
| • Prokinetic Drugs | Metocloprapmide (Reglan) |
| • Drugs for constipation | • Bisacodyl (dulcolax) • Fiber • Magnesium oxide and sodium phosphate) • Docusate (Colace, Surfak) • Lubiprostone (Amitiza) • Polyethylene glycol (Miralax) |
| • Antidiarrheal drugs | • Loperamide (Imodium) • Diphenoxylate (Lomotil) • Alosetron (Lotronex) |
| • Antiemetic agents | • Other anitemetics • Neurokinin-1 receptor antagonist • Serotonin 5HT-3 antagonists |
| H2 receptor antagonists | • Ranitidine (Zantac) • Famotidine (Pepcid) • Rizatidine (Axid) • Cimetidine (Tagament) |
| • Proton Pump Inhibitors | • Omeprazole (Prilosec) • Esomeprazole (Nexium) • Lansoprazole (Prevacid) • Deslansoprazole (Dexilent) • Pantoprazole (Protonix) • Rabeprazole (Aciphex) |
| • Gastric Antacids | • Aluminum and magnesium hydroxides • Calcium carbonate |
| • Cytoprotective Drugs | • Misoprostol (Cytotec) • Sucralfate (Carafate) |
| • Drugs for Inflammatory Bowel Diseases | • Mesalamine (Asacol) (Pentasa) (Rowasa) (Canasa) • Sulfasalazine (Azulfidine) • Budesonide (Entecort) • Other steroids (hydrocortisone, et al) • Biologics (infliximab and other -mabs) |
| • Serotonin 5HT-3 antagonists | • Ondansetron (Zofran) • Other -setrons |
| • Neurokinin-1 receptor antagonist | • Aprepitant (Amend) |
| • Other anitemetics | • Promethazine (Phenergan) • Dimenhyrinate (Dramamine) • Meclizine (Antivert) • Dronabinol (Marinol) • Dexamethasone (Decadron) |
| H2 Blockers | Indications: GERD (gastroesophageal reflux disease), dyspepsia, PUD (peptic ulcer disease), H. pylori |
| H2 Blockers adverse effects | HA, dizziness, constipation |
| Proton pump inhibitors | Indications: PUD, Zollinger-Ellison, gastrinomas, GERD, dyspepsia, NSAID use, h. pylori |
| Proton pump inhibitors Adverse effects: | skin rash, elevated liver enzymes, minor GI and CNS |
| Antacids | Indications: PUD, acid indigestion, dyspepsia |
| Antacids Adverse effects: | Magnesium – diarrhea ; Aluminum & calcium – constipation |
| Proton pumps | are in the gastric parietal cells. Prevent secretion of gastric acid for an extended period of time. |
| hydrocortisone, sulfasalazine (Azulfadine), infiximab (Remicade), mesalamine (Pentasa) | Indications: ulcerative colitis & Crohn’s |
| Glucocorticoids (hydrocortisone) | – induce remission |
| Aminosalicylates (sulfasalazine (Azulfadine),) mesalamine (Pentasa) | induce & maintain remission |
| Disease Modifying Antirheumatic Drugs (DMARDs) (infiximab (Remicade)) | Maintain remission |
| GI Motility Disorders | Constipation; Diarrhea; GERD; Gastroparesis; Chronic ; Acute; Diabetic; Irritable bowel disease (IBS) |
| o Metocloprapmide (Reglan) | Indications GERD, diabetic gastroparesis, antiemetic, intubation of the bowel |
| Metocloprapmide (Reglan) ADVERSE | CNS (drowsiness, EPS, seizures); Contraindications: seizure disorder, GI obstruction or hemorrhage, pheochromocytoma |
| docusate sodium (Colace) | Surfactant: Soften stool |
| bisacodyl (Dulcolax) | Stimulant - Adverse effects: abdominal cramping |
| lubiprostone (Amitiza) | Indications: Chronic idiopathic constipation ; IBS |
| lubiprostone (Amitiza) | Adverse effects: Nausea; Diarrhea |
| Opioid drugs | diphenoxylate (Lomotil)-RX; loperamide (Imodium)-OTC |
| Serotonin 5-HT3 blockers: ondansetron (Zofran) | Indications: Chemo-related/radiation N & V; Post-op ; Used in pregancy - Cat B |
| Serotonin 5-HT3 blockers | Adverse effects HA Constipation Diarrhea |
| aprepitant (Emend)(Neurokinin – Blocker ) | Indications: chemo; Use in combo with 5-HT blocker |
| Dopamine D2 Blockers (metoclopramide (Reglan); prochlorperazine (Compazine)) | Indications: N & V |
| Dopamine D2 Blockers | Adverse effects: Anticholinergic effects |
| Constipation | laxatives |
| docusate sodium (surfactant laxatives) | stool softeners: incorporate water into fatty intestinal material => soften feces => for those who have hard or dry, irritating or painful passage of stool |
| magnesium oxide (milk of magnesia) (osmotic laxatives) | attract and retain water , stimulate peristalsis |
| bisacodyl (stimulant laxatives) | evacuating the bowel before surgery or examination (oral or rectal) |
| bisacodyl adverse effect | abdominal cramping, electrolyte and fluid depletion |
| bisadodyl | short term treatment of constipation |
| magnesium and sodium adverse effects | excessive eloss of fluid and electrolytes, not for chronic constipation |
| lubiprostone indications | chronic idiopathic constipation: abdominal pain, bloating , hard or lumpy stool |
| lubiprostone adverse effects | nausea, diarrhea |
| PPIs | the most effective drugs fro treating GERD |
| PPIs special choice | for pts with Zollinger-Ellison syndrome (a condition with severe ulcers resulting from gastrin-secreting tumors) |
| PPI moa | inhibit the proton pump and prevent the secretion of gastric acid for an extended period of time. |
| gastric antacids | neutralize stomach acid, raise GI pH to relieve the pain of dyspepsia and acid indigestion and enable PUD to heal |
| gastric antacids | available without a prescription to treat acid indigestion and dyspepsia |
| PPI or H2 blockers | PPI are preferred for PUD because they heal 80% to 100% of ulcers in 4 weeks whereas H2 blockers require 6 to 8 weeks |
| Sucralfate indications | PUD: treat active ulcers and suppress recurrence ulcers |
| Sucralfate adverse effect | constipation, GI, Laryngospasm |
| Sucralfate adverse effect | cause Laryngospasm |
| Misoprostol: | prevention of gastric and duodenal ulcers |
| Misoprostol contraindication | Pregnancy |
| Misoprostol adverse effects | diarrhea, intestinal cramping, GI reactions |
| metochopramide | inhibit vomiting |
| metochopramide | D2 recepter antagonist |
| dronabinol | for cancer chemotherapy induced emesis, appetite stimulant for anorexic pt with AIDs |
| aprepitant | prevent emesis , prevent acute and delayed nausea and vomiting occuring with highly emetogenic cancer chemotherapy |
| peptic ulcers | too much of gastric acid secretions |
| primary gastric acid inhibitors | H2 antagonist and Proton pump inhibitors |
| Gastric antacids | relieve heartburn and dyspepsia |
Created by:
prinluu
Popular Science sets