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VNSG 1231 Exam 3

Chapter 9 Antibacterial Drugs

QuestionAnswer
the ability of a bacterium to resist the effects of antibacterials Antibiotic resistance
a drug that reduces the number of bacteria by killing them directly bactericidal
a drug that reduces the number of bacteria by preventing them form dividing and growing rather than directly killing them bacteriostatic
stage of drug development in which later generations are changed slightly to improve their effectiveness or means of administration drug generation
invasion by microorganisms that disturb the normal environment and cause harm or disease Infection
bacteria or other organisms that do not overgrow or cause infection, systemic disease or tissue damage nonpathogenic organisms
bacteria or other organisms that cause infection only when immune system is suppressed opportunistic organisms
bacteria or other organism that causes infection pathogenic organisms
a measure of how many different types of bacteria a drug can kill or prevent from growing spectrum of efficacy
bacteria or other organism that either can be killed by or have their reproduction reduced by an antibacterial drug susceptible organisms
the measure of how well bacteria can invade and spread despite a normal immune response virulence
also known as blood poisoning sepsis
disappearance of s/s of infection intended responses of antibacterial therapy
Diarrhea, thrush, vaginal yeast infections Side effects of antibacterial therapy
allergic reactions, anaphylaxis, pseudomembranous colitis Adverse effects of antibacterial therapy
Four types of antibacterial drugs Cell wall synthesis, protein synthesis inhibitors, metabolism inhibitors, and DNA synthesis inhibitors
Bactericidal, prevent bacteria from forming cell walls are intended responses for what type of antibacterial drug Cell wall synthesis inhibitors
with vancomycin and carbapenems nausea/vomitting, chills, red mans syndrome, reduced hearing and kidney function side effects of cell wall synthesis inhibitors
CNS changes and kidney damage, can also cause confusion or seizures Adverse effects of cell wall synthesis
cell wall inhibitors are bactericidal or bacteriostatic? Bactericidal
oral cepahlosporins are absorbed slow with iron supplements and antacids so give when one hour before or four hours after the dose of antacid
how slow should you give vancomycin at least over 60 minutes IV
in older adults these anitbacterial drugs can cause otoxicity, nephrotoxicity more likely Cell wall synthesis inhibitors
Protein synthesis inhibitors are bactericidal or bacteriostatic They are both
Nausea, vomiting, rash, fever, and lethargy common side effects of Aminoglycosides
Nausea, vomiting, diarrhea, loss of appetite, and photosensitivity common side effects of Marcolides
Nausea vomiting, diarrhea, sore tongue, and photosensitivity---More likely to promote yeast infections Tetracyclines
This medication is usually bacteriostatic but if given in high doses it can be bactericidal Clyndamycin
ototoxity, nephrotoxicity, and neuromuscular blockage adverse effects of Aminoglycosides
Many serious drug interactions-especially Coumadin, and Digoxin adverse effects of Marcolides
Increased cranial pressure, dizziness, confusion, and blurred vision adverse effects of Tetracyclines
reduced liver function, decreased WBC count, if infused too rapidly cardiac arrest or shock could occur adverse effects of Clindamycin
assess breathing baseline, lab tests, and hearing Things you should check before giving Aminoglycides
Other medications, and give erythromycin with eight hours of dilution things you should check before giving Marcolides
food (take meds 1 hour before or 2 hours after a meal), antacids, dairy products decrease absorption Things you should check before giving Tetracyclines
take with food to decrease GI side effects and avoid sun exposure Patient teaching for Marcolides
avoid sun exposure and do not take with food or milk Patient teaching for Tetracyclines
avoid taking foods containing tyramine Patient teaching for Linezolid
some food contain this and it can result in high BP Tyramine
otoxicity and nephrotoxicity more likley---monitor output closely Older adults taking Protein synthesis inhibitors
type of chemical can easily turn into crystals that form kidney stones Sulfonamides
HA, fever, skin rash, and photosensitivity Metabolism Inhibitors
suppression of bone marrow cell division(monitor RBC and WBC) and Steven Johnson syndrome adverse effects of metabolism inhibitors
includes skin peeling, sloughing off, and blisters Steven-Johnson syndrome
Sulfa allergies, blood disorders, and lab tests Things to check before giving Metabolism inhibitors
Jaundice, bruises, blisters and offer water every four hours things to check after administering meds
avoid sunlight, take with full glass of water, and drink more water to prevent crystalluria patient teaching for metabolism inhibitors
have more intense side effects and anemia, increased risk for bleeding older adult considerations while taking metabolism inhibitors
inhibit production of DNA, preventing bacterial reproduction DNA synthesis inhibitors
these drugs can concentrate in urine and make urine painful DNA synthesis inhibitors
causes serious heart dsyrhythmias, neurotoxicity, changes in glucose levels adverse effects of taking DNA inhibitors
tendon rupture is more common with older adults taking Fluoroquinolones
caused by overused, overprescribed, improperly taken antibacterial drugs Antibacterial drug resistance
Created by: nursekk